The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003141 Q13547 HDAC1
HDAC1_HUMAN
411 428 SDKRIACEEEFSDSEEEGEG TP 7SME  
Homo sapiens (Human) 482

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0114 x-ray crystallography in vitro Putta,2022 support certain InteractionDetection FeatureDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Putta,2022 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Putta,2022 support certain FeatureDetection
experimental MI:0905 amplified luminescent proximity homogeneous assay Putta,2022 support certain InteractionDetection
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Vortmeyer,1999 support certain
experimental MI:0065 isothermal titration calorimetry in vitro Singh,2005 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Vortmeyer,1999 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Vortmeyer,1999 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Ferreira,1998 support certain FeatureDetection
experimental MI:0405 competition binding in vitro Ferreira,1998 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Ferreira,1998 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Luo,1998 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Magnaghi-Jaulin,1998 support certain FeatureDetection
experimental MI:0405 competition binding in vitro Magnaghi-Jaulin,1998 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Magnaghi-Jaulin,1998 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Brehm,1998 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Brehm,1998 contradict likely InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Brehm,1998 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06400) RB_HUMAN PF01857 (RB_B)
Retinoblastoma-associated protein B domain
646 765 10.0/10.0 [mitab][xml]
(P28749) RBL1_HUMAN IPR002719 (Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno...
787 943 80.0/80.0 [mitab][xml]

o  Pathways

KEGG: The sequence Q13547 is implicated in the following 15 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org