The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
TRAF2 binding site
Functional site description:
Endogenous TRAF2 is a cytosolic protein that is recruited to membrane associated receptors.
ELMs with same func. site: LIG_TRAF2_1  LIG_TRAF2_2 
ELM Description:
Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails.
Pattern: [PSAT].[QE]E
Pattern Probability: 0.0042998
Present in taxon: Eukaryota
Interaction Domain:
MATH (PF00917) MATH domain (Stochiometry: 1 : 1)
PDB Structure: 1D0A
o See 14 Instances for LIG_TRAF2_1
o Abstract
The cell activation, cell survival, and antiapoptotic functions of the tumor necrosis factor (TNF) receptor superfamily are mostly mediated by the family of the TNF receptor-associated factors (TRAF1-6). The TRAF proteins are found in Mammalia, TAXON:7215, Caenorhabditis elegans, and Dictyostelium discoideum. Most of the biological effects are mediated by the activation of the transcriptional factor NF-kB and Ap-1 family, which can turn on numerous genes involved in various aspects of cellular and immune functions.
TRAF2 was isolated biochemically from the TNFR-2 signaling complex and is the prototype of the six TRAF family members. Beside TNFR-2, a number of other TNFRs such as CD30, CD40, CD27, Ox40, 4-1BB, and ATAR also recruit TRAF2. In addition, the transforming effect of the Epstein-Barr virus (EBV) oncoprotein latent infection membrane protein-1 (LMP1) is partly TRAF2 mediated. Several linear consensus sequences have been proposed to bind to TRAF2, including PXQX[TSD] motif in LMP1, CD30, CD40, and CD27; the phiSXEE ( phi = large hydrophobic) sequence in TNFR-2 and CD30; and the QEE motif in 4-1BB and Ox40 receptors. Despite the apparent sequence diversity, the receptor peptides bind to a common site on the surface of the TRAF domain of TRAF2. Crystal structures of the human TRAF2 domain in complex with peptides from the TNFR family members revealed a conserved binding mode and allowed to identify two consensus sequences.
o 3 selected references:

o 3 GO-Terms:

o 14 Instances for LIG_TRAF2_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P25942 CD40
104 107 TSETDTICTCEEGWHCTSEA FP 2 Homo sapiens (Human)
P18347 1
60 63 NPYCLLGHPVQESGCPGRPT TP 3 Herpesvirus saimiri (strain 11)
P28908 TNFRSF8
578 581 GSCSDVMLSVEEEGKEDPLP TP 2 Homo sapiens (Human)
P25942 CD40
250 253 LPGSNTAAPVQETLHGCQPV TP 2 Homo sapiens (Human)
P43489 TNFRSF4
262 265 PGGGSFRTPIQEEQADAHST TP 2 Homo sapiens (Human)
P36941 LTBR
402 405 PGPPGLSTPHQEDGKAWHLA TP 2 Homo sapiens (Human)
424 427 PKDEQVPFSKEECAFRSQLE TP 2 Homo sapiens (Human)
129 132 RPGWYCALSKQEGCRLCAPL FP 1 Homo sapiens (Human)
Q92956 TNFRSF14
268 271 APPDVTTVAVEETIPSFTGR TP 1 Homo sapiens (Human)
Q92956 TNFRSF14
175 178 PGTFSPNGTLEECQHQTKCS FP 1 Homo sapiens (Human)
P28908 TNFRSF8
561 564 EADHTPHYPEQETEPPLGSC TP 1 Homo sapiens (Human)
P26842 CD27
246 249 REEEGSTIPIQEDYRKPEPA TP 1 Homo sapiens (Human)
Q07011 TNFRSF9
246 249 QEEDGCSCRFPEEEEGGCEL TP 2 Homo sapiens (Human)
Q07011 TNFRSF9
234 237 QPFMRPVQTTQEEDGCSCRF TP 2 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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