The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003872 B7UM99 tir
TIR_ECO27
474 478 HQPEEHIYDEVAADPGYSVI TP 2CI9  
2CIA  
Escherichia coli O127:H6 str. E2348/69 550

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0051 fluorescence technology Gruenheid,2001 support certain InteractionDetection
experimental MI:0047 far western blotting in vitro Gruenheid,2001 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Gruenheid,2001 support certain FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Gruenheid,2001 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Frese,2006 support certain InteractionDetection FeatureDetection
experimental MI:0107 surface plasmon resonance in vitro Frese,2006 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P16333) NCK1_HUMAN PF00017 (SH2)
SH2 domain
282 356 0.05/0.07 [mitab][xml]
(Q99M51) NCK1_MOUSE PF00017 (SH2)
SH2 domain
282 356 0.313/0.313 [mitab][xml]
(O43639) NCK2_HUMAN PF00017 (SH2)
SH2 domain
285 359 0.33/0.41 [mitab][xml]
(O55033) NCK2_MOUSE PF00017 (SH2)
SH2 domain
285 359 0.313/0.313 [mitab][xml]
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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