| ELM Identifier | Description | RegEx | Instances | Instances in PDB | Articles.ELM |
|---|---|---|---|---|---|
| DEG_SCF_SKP2-CKS1_1 | Degradation motif recognised by a pre-assembled complex consisting of Skp2 (an F box protein of the SCF E3 ubiquitin ligase) and Cks1, which leads to ubiquitylation and subsequent proteosomal degradation. | ..[DE].(T)P.K | 3 | 1 | articles.ELM |
| DOC_CKS1_1 | Phospho-dependent motif that mediates docking of CDK substrates and regulators to cyclin-CDK-bound Cks1. | [MPVLIFWYQ].(T)P.. | 8 | 1 | articles.ELM |
| DOC_CYCLIN_RxL_1 | Both fungal and mammalian S-phase Cyclin/CDK complexes recognize specific RxL docking motifs in their target proteins. | (.|([KRH].{0,3}))[^EDWNSG][^D][RK][^D]L.{0,1}[FL].{0,3}[EDST] | 31 | 7 | articles.ELM |
| MOD_AAK1BIKe_LxxQxTG_1 | Motif that is phosphorylated by the endocytic kinases AAK1 and/or BIKe | [LIVM][^D][^DEHYWF]Q.(T)G | 17 | 0 | articles.ELM |
| MOD_ASX_betaOH_EGF | ASX hydroxylation of some EGF domains. | C.([DN]).{4,4}[FY].C.C | 6 | 0 | articles.ELM |
| MOD_CAAXbox | Generic CAAX box prenylation motif | (C)[^DENQ][LIVMF].$ | 17 | 2 | articles.ELM |
| MOD_CDC14_SPxK_1 | A subset of Cdk phosphorylation sites conform to the (S)PxK/r pattern that serves as an optimal Cdc14 dephosphorylation site, allowing high catalytic efficiency. | (S)P.[KR] | 48 | 0 | articles.ELM |
| MOD_CDK_SPK_2 | Short version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST] +2 position. | ...([ST])P[RK] | 18 | 0 | articles.ELM |
| MOD_CDK_SPxK_1 | Canonical version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST]+3 position. | ...([ST])P.[KR] | 26 | 1 | articles.ELM |
| MOD_CDK_SPxxK_3 | Longer version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at position +4 after the phospho-Ser/Thr |
...([ST])P..[RK] | 25 | 0 | articles.ELM |
| MOD_CK1_1 | CK1 phosphorylation site | S..([ST])... | 27 | 0 | articles.ELM |
| MOD_CK2_1 | Casein kinase 2 (CK2) phosphorylation site | ...([ST])..E | 34 | 0 | articles.ELM |
| MOD_CMANNOS | Motif for attachment of a mannosyl residue to a tryptophan | (W)..W | 24 | 0 | articles.ELM |
| MOD_Cter_Amidation | Peptide C-terminal amidation | (.)G[RK][RK] | 0 | 0 | articles.ELM |
| MOD_DYRK1A_RPxSP_1 | Serine/Threonine residue phosphorylated by Argininine and Proline directed DYRK1A kinase. | R[PSVA].([ST])P | 22 | 1 | articles.ELM |
| MOD_GlcNHglycan | Glycosaminoglycan attachment site | [ED]{0,3}.(S)[GA]. | 6 | 0 | articles.ELM |
| MOD_GSK3_1 | GSK3 phosphorylation recognition site | ...([ST])...[ST] | 22 | 0 | articles.ELM |
| MOD_LATS_1 | The LATS phosphorylation motif is recognised by the LATS kinases for Ser/Thr phosphorylation. Substrates are often found toward the end of the Hippo signalling pathway. | H.[KR]..([ST])[^P] | 23 | 0 | articles.ELM |
| MOD_LOK_YxT_1 | The optimal phosphorylation site of the basophilic lymphocyte-oriented kinase (LOK) and SLK that mainly regulate cell shape and motility. | [KR][YF][^IVEDPGAC](T)[LMIVWFY][RKH] | 5 | 0 | articles.ELM |
| MOD_NEK2_1 | Strict version of the motif targeted by NEK2 for phosphorylation | [FLM][^PVIED][^PVID]([ST])[MLIVF][RKH]. | 2 | 0 | articles.ELM |
| MOD_NEK2_2 | The more tolerant version of the Nek2 phosphosite motif | [FLMW][^P][^P]([ST])[^PDEGAN][RKH]. | 0 | 0 | articles.ELM |
| MOD_N-GLC_1 | Generic motif for N-glycosylation. It was shown that Trp, Asp, and Glu are uncommon before the Ser/Thr position. Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus. | .(N)[^P][ST].. | 156 | 1 | articles.ELM |
| MOD_N-GLC_2 | Atipical motif for N-glycosylation site. Examples are Human CD69, which is uniquely glycosylated at typical (Asn-X-Ser/Thr) and atypical (Asn-X-Cys) motifs, beta protein C | (N)[^P]C | 5 | 0 | articles.ELM |
| MOD_NMyristoyl | Generic motif for N-Myristoylation site. | ^M{0,1}(G)[^EDRKHPFYW]..[STAGCN][^P] | 50 | 7 | articles.ELM |
| MOD_OFUCOSY | Site for attachment of a fucose residue to a serine. | C.{3,5}([ST])C | 4 | 0 | articles.ELM |
| MOD_OGLYCOS | Site for attachment of a glucose residue to a serine. | C.(S).PC | 2 | 0 | articles.ELM |
| MOD_PIKK_1 | (ST)Q motif which is phosphorylated by PIKK family members. | ...([ST])Q.. | 48 | 0 | articles.ELM |
| MOD_PK_1 | Phosphorylase kinase phosphorylation site | [RK]..(S)[VI].. | 1 | 0 | articles.ELM |
| MOD_PKA_1 | Main preference for PKA-type AGC kinase phosphorylation. | [RK][RK].([ST])[^P].. | 25 | 0 | articles.ELM |
| MOD_PKA_2 | Secondary preference for PKA-type AGC kinase phosphorylation. | .R.([ST])[^P].. | 28 | 0 | articles.ELM |
| MOD_PKB_1 | PKB Phosphorylation site | R.R..([ST])[^P].. | 20 | 1 | articles.ELM |
| MOD_Plk_1 | Ser/Thr residue phosphorylated by the Plk1 kinase | .[DNE][^PG][ST](([FYILMVW]..)|([^PEDGKN][FWYLIVM]).) | 44 | 0 | articles.ELM |
| MOD_Plk_2-3 | Ser/Thr residue phosphorylated by Plk2 and Plk3 | [DE]..([ST])[EDILMVFWY](([DE].)|(.[DE])) | 3 | 0 | articles.ELM |
| MOD_Plk_4 | Ser/Thr residue phosphorylated by Plk4 | ..[^IRFW]([ST])[ILMVFWY][ILMVFWY]. | 7 | 0 | articles.ELM |
| MOD_PRMT_GGRGG_1 | A GGRGG motif recognized by the arginine methyl transferase for arginine methylation | GGRGG | 24 | 0 | articles.ELM |
| MOD_ProDKin_1 | Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes. | ...([ST])P.. | 38 | 0 | articles.ELM |
| MOD_SPalmitoyl_2 | Class 2 Palmitoylation motif | G(C)M[GS][CL][KP]C | 2 | 0 | articles.ELM |
| MOD_SPalmitoyl_4 | Class 4 palmitoylation motif | ^M{0,1}G(C)..S[AKS] | 6 | 0 | articles.ELM |
| MOD_SUMO_for_1 | Motif recognised for modification by SUMO-1 | [VILMAFP](K).E | 46 | 1 | articles.ELM |
| MOD_SUMO_rev_2 | Inverted version of SUMOylation motif recognized for modification by SUMO-1 | [SDE].{0,5}[DE].(K).{0,1}[AIFLMPSTV] | 20 | 0 | articles.ELM |
| MOD_TYR_CSK | Members of the non-receptor tyrosine kinase Csk family phosphorylate the C-terminal tyrosine residues of the Src family. | [TAD][EA].Q(Y)[QE].[GQA][PEDLS] | 12 | 0 | articles.ELM |
| MOD_TYR_DYR | The kinase activity of the DYRK (dual specificity kinase) is dependent on the autophosphorylation of the YXY motif in the activation loop. | ..[RKTC][IVL]Y[TQHS](Y)[IL]QSR | 9 | 0 | articles.ELM |
| MOD_WntLipid | Palmitoylation site in WNT signalling proteins that is required for correct processing in the endoplasmic reticulum. | [ETA](C)[QERK]..F...RWNC[ST] | 1 | 0 | articles.ELM |
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DEGHide/Show instances of class type DEG (degradation sites)
DOCHide/Show instances of class type DOC (docking sites)
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Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
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ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement