The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
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293 interaction domains annotated in ELM

ELM identifierInteraction Domain IdInteraction Domain NameInteraction Domain Description
CLV_NRD_NRD_1 PF00675 Peptidase_M16 Insulinase (Peptidase family M16)
CLV_PCSK_FUR_1 PF00082 Peptidase_S8 Subtilase family
CLV_PCSK_PC1ET2_1 PF00082 Peptidase_S8 Subtilase family
CLV_PCSK_PC7_1 PF00082 Peptidase_S8 Subtilase family
CLV_PCSK_SKI1_1 PF00082 Peptidase_S8 Subtilase family
CLV_TASPASE1 PF01112 Asparaginase_2 Asparaginase
old_LIG_14-3-3_1 PF00244 14-3-3 14-3-3 protein
old_LIG_14-3-3_2 PF00244 14-3-3 14-3-3 protein
old_LIG_14-3-3_3 PF00244 14-3-3 14-3-3 protein
LIG_AP_GAE_1 PF02883 Alpha_adaptinC2 Adaptin C-terminal domain
LIG_AP2alpha_1 PF02296 Alpha_adaptin_C Alpha adaptin AP2, C-terminal domain
LIG_AP2alpha_2 PF02296 Alpha_adaptin_C Alpha adaptin AP2, C-terminal domain
DEG_APCC_DBOX_1 PF00400 WD40 WD domain, G-beta repeat
DEG_APCC_KENBOX_2 PF00400 WD40 WD domain, G-beta repeat
LIG_BIR_II_1 PF00653 BIR Inhibitor of Apoptosis domain
LIG_BIR_III_1 PF00653 BIR Inhibitor of Apoptosis domain
LIG_BIR_III_2 PF00653 BIR Inhibitor of Apoptosis domain
LIG_BIR_III_3 PF00653 BIR Inhibitor of Apoptosis domain
LIG_BIR_III_4 PF00653 BIR Inhibitor of Apoptosis domain
LIG_BRCT_BRCA1_1 PF00533 BRCT BRCA1 C Terminus (BRCT) domain
LIG_BRCT_BRCA1_2 PF00533 BRCT BRCA1 C Terminus (BRCT) domain
LIG_BRCT_MDC1_1 PF00533 BRCT BRCA1 C Terminus (BRCT) domain
LIG_CAP-Gly_1 PF01302 CAP_GLY CAP-Gly domain
LIG_Clathr_ClatBox_1 PF01394 Clathrin_propel Clathrin propeller repeat
LIG_Clathr_ClatBox_2 PF01394 Clathrin_propel Clathrin propeller repeat
DEG_COP1 PF00400 WD40 WD domain, G-beta repeat
LIG_CORNRBOX PF00104 Hormone_recep Ligand-binding domain of nuclear hormone receptor
LIG_CtBP_PxDLS_1 PF00389 2-Hacid_dh D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
DOC_CYCLIN_1 PF00134 Cyclin_N Cyclin, N-terminal domain
LIG_Dynein_DLC8_1 PF01221 Dynein_light Dynein light chain type 1
LIG_EH1_1 PF00400 WD40 WD domain, G-beta repeat
LIG_FAT_LD_1 PF03623 Focal_AT Focal adhesion targeting region
LIG_FHA_1 PF00498 FHA FHA domain
LIG_FHA_2 PF00498 FHA FHA domain
LIG_GLEBS_BUB3_1 PF00400 WD40 WD domain, G-beta repeat
LIG_GYF PF02213 GYF GYF domain
LIG_HOMEOBOX PF00046 Homeobox Homeobox domain
LIG_HP1_1 PF01393 Chromo_shadow Chromo shadow domain
LIG_IBS_1 PF00092 VWA von Willebrand factor type A domain
LIG_CaM_IQ_9 PF00036 efhand EF hand
LIG_LYPXL_L_2 PF13949 ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV
LIG_LYPXL_S_1 PF13949 ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV
LIG_MAD2 PF02301 HORMA HORMA domain
DOC_MAPK_gen_1 PF00069 Pkinase Protein kinase domain
DOC_MAPK_FxFP_2 PF00069 Pkinase Protein kinase domain
DEG_MDM2_SWIB_1 PF02201 SWIB SWIB/MDM2 domain
LIG_MYND_1 PF01753 zf-MYND MYND finger
LIG_NRBOX PF00104 Hormone_recep Ligand-binding domain of nuclear hormone receptor
DEG_ODPH_VHL_1 PF01847 VHL von Hippel-Lindau disease tumour suppressor protein
LIG_PCNA_PIPBox_1 PF02747 PCNA_C Proliferating cell nuclear antigen, C-terminal domain
LIG_PDZ_Class_1 PF00595 PDZ PDZ domain (Also known as DHR or GLGF)
LIG_PDZ_Class_2 PF00595 PDZ PDZ domain (Also known as DHR or GLGF)
LIG_PDZ_Class_3 PF00595 PDZ PDZ domain (Also known as DHR or GLGF)
DOC_PP1_RVXF_1 PF00149 Metallophos Calcineurin-like phosphoesterase
DOC_PP2B_PxIxI_1 PF00149 Metallophos Calcineurin-like phosphoesterase
LIG_PTAP_UEV_1 PF05743 UEV UEV domain
LIG_PTB_Phospho_1 PF02174 IRS PTB domain (IRS-1 type)
LIG_PTB_Phospho_1 PF00640 PID Phosphotyrosine interaction domain (PTB/PID)
LIG_PTB_Phospho_1 PF08416 PTB Phosphotyrosine-binding domain
LIG_PTB_Phospho_1 PF10480 ICAP-1_inte_bdg Beta-1 integrin binding protein
LIG_PTB_Apo_2 PF00640 PID Phosphotyrosine interaction domain (PTB/PID)
LIG_PTB_Apo_2 PF02174 IRS PTB domain (IRS-1 type)
DOC_WD40_RPTOR_TOS_1 PF00400 WD40 WD domain, G-beta repeat
LIG_Rb_LxCxE_1 PF01857 RB_B Retinoblastoma-associated protein B domain
LIG_RRM_PRI_1 PF10378 RRM Putative RRM domain
DEG_SCF_FBW7_1 PF00400 WD40 WD domain, G-beta repeat
DEG_SCF_FBW7_2 PF00400 WD40 WD domain, G-beta repeat
DEG_SCF_TRCP1_1 PF00400 WD40 WD domain, G-beta repeat
LIG_SH2_GRB2 PF00017 SH2 SH2 domain
LIG_SH2_PTP2 PF00017 SH2 SH2 domain
LIG_SH2_SRC PF00017 SH2 SH2 domain
LIG_SH2_STAT3 PF00017 SH2 SH2 domain
LIG_SH2_STAT5 PF00017 SH2 SH2 domain
LIG_SH2_STAT6 PF00017 SH2 SH2 domain
LIG_SH3_1 PF00018 SH3_1 SH3 domain
LIG_SH3_2 PF00018 SH3_1 SH3 domain
LIG_SH3_3 PF00018 SH3_1 SH3 domain
LIG_SH3_4 PF00018 SH3_1 SH3 domain
LIG_SH3_5 PF00018 SH3_1 SH3 domain
DEG_SIAH_1 PF03145 Sina Seven in absentia protein family
LIG_Sin3_1 PF02671 PAH Paired amphipathic helix repeat
LIG_Sin3_2 PF02671 PAH Paired amphipathic helix repeat
LIG_Sin3_3 PF02671 PAH Paired amphipathic helix repeat
DOC_SPAK_OSR1_1 PF12202 OSR1_C Oxidative-stress-responsive kinase 1 C terminal
LIG_SxIP_EBH_1 PF03271 EB1 EB1-like C-terminal motif
DOC_ANK_TNKS_1 PF00023 Ank Ankyrin repeat
LIG_TPR PF00515 TPR_1 Tetratricopeptide repeat
LIG_TRAF2_1 PF00917 MATH MATH domain
LIG_TRAF2_2 PF00917 MATH MATH domain
LIG_TRAF6 PF00917 MATH MATH domain
LIG_TRFH_1 PF08558 TRF Telomere repeat binding factor (TRF)
LIG_ULM_U2AF65_1 PF00076 RRM_1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DOC_USP7_MATH_1 PF00917 MATH MATH domain
DOC_USP7_MATH_2 PF00917 MATH MATH domain
LIG_WH1 PF00568 WH1 WH1 domain
LIG_WRPW_1 PF00400 WD40 WD domain, G-beta repeat
LIG_WRPW_2 PF00400 WD40 WD domain, G-beta repeat
LIG_WW_1 PF00397 WW WW domain
LIG_WW_2 PF00397 WW WW domain
LIG_WW_3 PF00397 WW WW domain
DOC_WW_Pin1_4 PF00397 WW WW domain
MOD_CAAXbox PF01239 PPTA Protein prenyltransferase alpha subunit repeat
MOD_CK1_1 PF00069 Pkinase Protein kinase domain
MOD_CK2_1 PF00069 Pkinase Protein kinase domain
MOD_CMANNOS PF00535 Glycos_transf_2 Glycosyl transferase family 2
MOD_GSK3_1 PF00069 Pkinase Protein kinase domain
MOD_N-GLC_1 PF02516 STT3 Oligosaccharyl transferase STT3 subunit
MOD_N-GLC_2 PF02516 STT3 Oligosaccharyl transferase STT3 subunit
MOD_OFUCOSY PF10250 O-FucT GDP-fucose protein O-fucosyltransferase
MOD_OGLYCOS PF02709 Galactosyl_T_2 Galactosyltransferase
MOD_PIKK_1 PF00454 PI3_PI4_kinase Phosphatidylinositol 3- and 4-kinase
MOD_PKB_1 PF00069 Pkinase Protein kinase domain
MOD_PLK PF00069 Pkinase Protein kinase domain
MOD_SPalmitoyl_2 PF01529 zf-DHHC DHHC zinc finger domain
MOD_SPalmitoyl_4 PF01529 zf-DHHC DHHC zinc finger domain
MOD_SUMO_for_1 PF00179 UQ_con Ubiquitin-conjugating enzyme
MOD_TYR_CSK PF07714 Pkinase_Tyr Protein tyrosine kinase
MOD_TYR_DYR PF00069 Pkinase Protein kinase domain
LIG_TYR_ITAM PF00017 SH2 SH2 domain
LIG_TYR_ITIM PF00017 SH2 SH2 domain
MOD_WntLipid PF03062 MBOAT MBOAT family
TRG_AP2beta_CARGO_1 PF09066 B2-adapt-app_C Beta2-adaptin appendage, C-terminal sub-domain
TRG_Cilium_Arf4_1 PF00025 Arf ADP-ribosylation factor family
TRG_ENDOCYTIC_2 PF00928 Adap_comp_sub Adaptor complexes medium subunit family
TRG_ER_FFAT_1 PF00635 Motile_Sperm MSP (Major sperm protein) domain
TRG_ER_KDEL_1 PF00810 ER_lumen_recept ER lumen protein retaining receptor
TRG_Golgi_diPhe_1 PF00400 WD40 WD domain, G-beta repeat
TRG_LysEnd_APsAcLL_1 PF01217 Clat_adaptor_s Clathrin adaptor complex small chain
TRG_LysEnd_APsAcLL_3 PF01217 Clat_adaptor_s Clathrin adaptor complex small chain
TRG_LysEnd_GGAAcLL_1 PF00790 VHS VHS domain
TRG_LysEnd_GGAAcLL_2 PF00790 VHS VHS domain
TRG_NES_CRM1_1 PF08389 Xpo1 Exportin 1-like protein
TRG_NLS_Bipartite_1 PF00514 Arm Armadillo/beta-catenin-like repeat
TRG_NLS_MonoCore_2 PF00514 Arm Armadillo/beta-catenin-like repeat
TRG_NLS_MonoExtC_3 PF00514 Arm Armadillo/beta-catenin-like repeat
TRG_NLS_MonoExtN_4 PF00514 Arm Armadillo/beta-catenin-like repeat
LIG_Pex14_1 PF00018 SH3_1 SH3 domain
TRG_PTS1 PF00515 TPR_1 Tetratricopeptide repeat
TRG_PTS2 PF00400 WD40 WD domain, G-beta repeat
DEG_SCF_SKP2-CKS1_1 PF00560 LRR_1 Leucine-rich repeat
LIG_Actin_RPEL_3 PF00022 Actin Actin
LIG_Actin_WH2_1 PF00022 Actin Actin
LIG_Actin_WH2_2 PF00022 Actin Actin
DOC_AGCK_PIF_1 PF00069 Pkinase Protein kinase domain
DOC_AGCK_PIF_2 PF00069 Pkinase Protein kinase domain
DOC_AGCK_PIF_3 PF00069 Pkinase Protein kinase domain
LIG_EH_1 PF00036 efhand EF hand
LIG_EVH1_1 PF00568 WH1 WH1 domain
LIG_EVH1_2 PF00568 WH1 WH1 domain
LIG_EVH1_3 PF00568 WH1 WH1 domain
LIG_Rb_pABgroove_1 PF01857 RB_B Retinoblastoma-associated protein B domain
LIG_Rb_pABgroove_1 PF01858 RB_A Retinoblastoma-associated protein A domain
LIG_RGD PF00362 Integrin_beta Integrin, beta chain
LIG_RGD PF01839 FG-GAP FG-GAP repeat
MOD_ASX_betaOH_EGF PF05118 Asp_Arg_Hydrox Aspartyl/Asparaginyl beta-hydroxylase
MOD_CDK_SPxK_1 PF00069 Pkinase Protein kinase domain
MOD_Cter_Amidation PF01082 Cu2_monooxygen Copper type II ascorbate-dependent monooxygenase, N-terminal domain
MOD_GlcNHglycan PF02485 Branch Core-2/I-Branching enzyme
MOD_GlcNHglycan PF01048 PNP_UDP_1 Phosphorylase superfamily
MOD_NMyristoyl PF02799 NMT_C Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain
MOD_PK_1 PF00069 Pkinase Protein kinase domain
MOD_PKA_1 PF00069 Pkinase Protein kinase domain
MOD_PKA_2 PF00069 Pkinase Protein kinase domain
MOD_ProDKin_1 PF00069 Pkinase Protein kinase domain
LIG_TYR_ITSM PF00017 SH2 SH2 domain
TRG_ER_diLys_1 PF00400 WD40 WD domain, G-beta repeat
LIG_SH3_2 PF07653 SH3_2 Variant SH3 domain
LIG_Actin_RPEL_3 PF02755 RPEL RPEL repeat
LIG_EH_1 PF12763 efhand_3 Cytoskeletal-regulatory complex EF hand
TRG_ER_diArg_1 PF00400 WD40 WD domain, G-beta repeat
DEG_CRL4_CDT2_1 PF02747 PCNA_C Proliferating cell nuclear antigen, C-terminal domain
DEG_CRL4_CDT2_1 PF00400 WD40 WD domain, G-beta repeat
DEG_CRL4_CDT2_2 PF02747 PCNA_C Proliferating cell nuclear antigen, C-terminal domain
DEG_CRL4_CDT2_2 PF00400 WD40 WD domain, G-beta repeat
LIG_Pex14_1 PF04695 Pex14_N Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_Pex14_2 PF04695 Pex14_N Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_Pex3_1 PF04882 Peroxin-3 Peroxin-3
LIG_Integrin_isoDGR_1 PF08441 Integrin_alpha2 Integrin alpha
LIG_Integrin_isoDGR_1 PF00362 Integrin_beta Integrin, beta chain
LIG_Integrin_isoDGR_1 PF01839 FG-GAP FG-GAP repeat
LIG_SPRY_1 PF00622 SPRY SPRY domain
LIG_PAM2_1 PF00658 PABP Poly-adenylate binding protein, unique domain
CLV_Separin_Fungi PF03568 Peptidase_C50 Peptidase family C50
CLV_Separin_Metazoa PF03568 Peptidase_C50 Peptidase family C50
LIG_CaM_IQ_9 PF13499 EF_hand_7 EF-hand domain pair
CLV_C14_Caspase3-7 PF00656 Peptidase_C14 Caspase domain
LIG_HCF-1_HBM_1 PF13415 Kelch_3 Galactose oxidase, central domain
DOC_PIKK_1 PF02985 HEAT HEAT repeat
LIG_eIF4E_1 PF01652 IF4E Eukaryotic initiation factor 4E
LIG_eIF4E_2 PF01652 IF4E Eukaryotic initiation factor 4E
MOD_LATS_1 PF00069 Pkinase Protein kinase domain
MOD_LATS_1 PF00433 Pkinase_C Protein kinase C terminal domain
MOD_NEK2_1 PF00069 Pkinase Protein kinase domain
MOD_NEK2_2 PF00069 Pkinase Protein kinase domain
LIG_EABR_CEP55_1 PF12180 EABR TSG101 and ALIX binding domain of CEP55
LIG_PAM2_2 PF00658 PABP Poly-adenylate binding protein, unique domain
LIG_MYND_2 PF01753 zf-MYND MYND finger
LIG_MYND_3 PF01753 zf-MYND MYND finger
DEG_APCC_TPR_1 SM00028 TPR Tetratricopeptide repeats.
LIG_NBox_RRM_1 PF00076 RRM_1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DEG_SCF_TIR1_1 SM00370 LRR Leucine-rich repeats, outliers
DEG_SCF_COI1_1 SM00370 LRR Leucine-rich repeats, outliers
DEG_Nend_UBRbox_4 PF02207 zf-UBR Putative zinc finger in N-recognin (UBR box)
DEG_Nend_UBRbox_1 PF02207 zf-UBR Putative zinc finger in N-recognin (UBR box)
DEG_Nend_UBRbox_2 PF02207 zf-UBR Putative zinc finger in N-recognin (UBR box)
DEG_Nend_UBRbox_3 PF02207 zf-UBR Putative zinc finger in N-recognin (UBR box)
LIG_CaMK_CASK_1 PF00069 Pkinase Protein kinase domain
LIG_SH3_2 PF14604 SH3_9 Variant SH3 domain
DOC_CKS1_1 PF01111 CKS Cyclin-dependent kinase regulatory subunit
LIG_SUFU_1 PF05076 SUFU Suppressor of fused protein (SUFU)
LIG_SUFU_1 PF12470 SUFU_C Suppressor of Fused Gli/Ci N terminal binding domain
DOC_PP1_SILK_1 PF00149 Metallophos Calcineurin-like phosphoesterase
LIG_WD40_WDR5_WIN_1 IPR017986 IPR017986 WD40-repeat-containing domain
LIG_WD40_WDR5_WIN_2 IPR017986 IPR017986 WD40-repeat-containing domain
LIG_WD40_WDR5_WIN_3 IPR017986 IPR017986 WD40-repeat-containing domain
LIG_WD40_WDR5_VDV_1 IPR017986 IPR017986 WD40-repeat-containing domain
LIG_WD40_WDR5_VDV_2 IPR017986 IPR017986 WD40-repeat-containing domain
DOC_PP2B_LxvP_1 PF00149 Metallophos Calcineurin-like phosphoesterase
DOC_PP2B_LxvP_1 PF13499 EF_hand_7 EF-hand domain pair
LIG_LIR_Gen_1 PF02991 Atg8 Autophagy protein Atg8 ubiquitin like
LIG_LIR_Apic_2 PF02991 Atg8 Autophagy protein Atg8 ubiquitin like
LIG_LIR_Nem_3 PF02991 Atg8 Autophagy protein Atg8 ubiquitin like
LIG_LIR_LC3C_4 PF02991 Atg8 Autophagy protein Atg8 ubiquitin like
LIG_EF_ALG2_ABM_1 SM00054 EFh EF-hand, calcium binding motif
LIG_EF_ALG2_ABM_2 SM00054 EFh EF-hand, calcium binding motif
DOC_PP1_MyPhoNE_1 PF00149 Metallophos Calcineurin-like phosphoesterase
LIG_CNOT1_NIM_1 PF04054 Not1 CCR4-Not complex component, Not1
DOC_PP2A_KARD_1 PF01603 B56 Protein phosphatase 2A regulatory B subunit (B56 family)
LIG_Pex14_3 PF04695 Pex14_N Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_Pex14_4 PF04695 Pex14_N Peroxisomal membrane anchor protein (Pex14p) conserved region
LIG_RPA_C_Vert PF08784 RPA_C Replication protein A C terminal
LIG_RPA_C_Plants PF08784 RPA_C Replication protein A C terminal
LIG_RPA_C_Insects PF08784 RPA_C Replication protein A C terminal
LIG_RPA_C_Fungi PF08784 RPA_C Replication protein A C terminal
LIG_Mtr4_Trf4_1 PF00270 DEAD DEAD/DEAH box helicase
LIG_Mtr4_Trf4_2 PF00270 DEAD DEAD/DEAH box helicase
LIG_Mtr4_Air2_1 PF00270 DEAD DEAD/DEAH box helicase
LIG_CID_NIM_1 IPR006569 CID domain The C-terminal domain (CTD) of the large subunit of RNA polymerase II is a platform for mRNA processing factors and links gene transcription to mRNA capping, splicing and polyadenylation. CTD recognition is dependent on the phosphorylation state of the CTD itself, which varies during the course of transcription but has also been linked to the isomerization state of the CTD's proline residues. Several RNA-processing factors recognise the CTD by means of a conserved CTD-interacting domain (CID). Factors with CID domains include the serine/arginine-rich-like factors SCAF4 and SCAF8, Nrd1 (which is implicated in polyadenylation-independent RNA 3'-end formation) and Pcf11. Pcf11 is a conserved and essential subunit of the yeast cleavage factor 1A, which is required for 3'-RNA processing and transcription termination [, ]. The CID domain is a right-handed superhelix of eight alpha-helices forming a compact domain. The CID fold closely resembles that of VHS domains and is related to armadillo-repeat proteins, except for the two amino-terminal helices. Amino acid residues in the hydrophobic core of the domain are highly conserved across CID domains [, ].
DEG_SPOP_SBC_1 PF00917 MATH MATH domain
DEG_Kelch_Keap1_1 PF01344 Kelch_1 Kelch motif
DEG_Kelch_Keap1_2 PF01344 Kelch_1 Kelch motif
DEG_Kelch_actinfilin_1 PF01344 Kelch_1 Kelch motif
DEG_Kelch_KLHL3_1 PF01344 Kelch_1 Kelch motif
MOD_SUMO_rev_2 PF00179 UQ_con Ubiquitin-conjugating enzyme
DOC_GSK3_Axin_1 PF00069 Pkinase Protein kinase domain
DOC_USP7_UBL2_3 PF12436 USP7_ICP0_bdg ICP0-binding domain of Ubiquitin-specific protease 7
LIG_DCNL_PONY_1 PF03556 Cullin_binding Cullin binding
LIG_LRP6_Inhibitor_1 PF00058 Ldl_recept_b Low-density lipoprotein receptor repeat class B
LIG_FZD_DVL_PDZ PF00595 PDZ PDZ domain (Also known as DHR or GLGF)
LIG_CaM_NSCaTE_8 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-26_7 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-17_6 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-8-9-10_5 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-8-14_4 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-5-10-14_3 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-8_REV_2 PF13499 EF_hand_7 EF-hand domain pair
LIG_CaM_1-14-15-16_REV_1 PF13499 EF_hand_7 EF-hand domain pair
LIG_GSK3_LRP6_1 PF00069 Pkinase Protein kinase domain
LIG_KLC1_WD_1 SM00028 TPR Tetratricopeptide repeats.
LIG_G3BP_FGDF_1 PF02136 NTF2 Nuclear transport factor 2 (NTF2) domain
LIG_CSL_BTD_1 PF09270 BTD Beta-trefoil DNA-binding domain
DOC_MAPK_RevD_3 PF00069 Pkinase Protein kinase domain
LIG_ANK_PxLPxL_1 PF00023 Ank Ankyrin repeat
LIG_ANK_PxLPxL_1 SM00248 ANK ankyrin repeats
LIG_14-3-3_CanoR_1 PF00244 14-3-3 14-3-3 protein
LIG_14-3-3_CterR_2 PF00244 14-3-3 14-3-3 protein
LIG_PALB2_WD40_1 PF16756 PALB2_WD40 Partner and localizer of BRCA2 WD40 domain
LIG_CAP-Gly_2 PF01302 CAP_GLY CAP-Gly domain
LIG_APCC_Cbox_2 PF00515 TPR_1 Tetratricopeptide repeat
LIG_APCC_Cbox_1 PF00515 TPR_1 Tetratricopeptide repeat
CLV_PCSK_KEX2_1 PF00082 Peptidase_S8 Subtilase family
CLV_MEL_PAP_1 PF00089 Trypsin Trypsin
LIG_SUMO_SIM_par_1 PF11976 Rad60-SLD Ubiquitin-2 like Rad60 SUMO-like
LIG_SUMO_SIM_anti_2 PF11976 Rad60-SLD Ubiquitin-2 like Rad60 SUMO-like
LIG_GBD_WASP_1 PF00786 PBD P21-Rho-binding domain
LIG_OCRL_FandH_1 PF00620 RhoGAP RhoGAP domain
LIG_UFM1_UFIM_1 PF03671 Ufm1 Ubiquitin fold modifier 1 protein
DOC_MAPK_JIP1_4 PF00069 Pkinase Protein kinase domain
DOC_MAPK_NFAT4_5 PF00069 Pkinase Protein kinase domain
LIG_CSK_EPIYA_1 PF00017 SH2 SH2 domain
DOC_PP2A_B56_1 IPR016024 Armadillo-type fold This entry represents a structural domain with an armadillo (ARM)-like fold, consisting of a multi-helical fold comprised of two curved layers of alpha helices arranged in a regular right-handed superhelix, where the repeats that make up this structure are arranged about a common axis [ ]. These superhelical structures present an extensive solvent-accessible surface that is well suited to binding large substrates such as proteins and nucleic acids. Domains and repeats with an ARM-like fold have been found in a number of proteins, including: ARM repeat domain, found in beta-catenins, importins, karyopherin and exportins. HEAT repeat domain, found in protein phosphatase 2a and initiation factor eIF4G. PHAT domain, found in the RNA-binding protein Smaug. Leucine-rich repeat variant, which contain an FeS cluster. Pumilo repeat domain, found in Pumilo protein. Regulatory subunit H of V-type ATPases. PBS lyase HEAT-like repeat. Mo25 protein. MIF4G domain-like, found in eukaryotic initiation factor eIF4G, translation initiation factor eIF-2b epsilon and nuclear cap-binding protein CBP80. The N-terminal domain of eukaryotic translation initiation factor 3 subunit 12. The C-terminal domain of leukotriene A4 hydrolase. The helical domain of phosphoinositide 3-kinase. The N-terminal fragment of adaptin alpha-C and beta subunits. The proximal leg segment and the linker domain of the clathrin heavy chain. The sequence similarity among these different repeats or domains is low, however they exhibit considerable structural similarity. Furthermore, the number of repeats present in the superhelical structure can vary between orthologues, indicating that rapid loss/gain of repeats has occurred frequently in evolution. A common phylogenetic origin has been proposed for the armadillo and HEAT repeats [ ].
DEG_COP1_1 PF00400 WD40 WD domain, G-beta repeat
LIG_BH_BH3_1 PF00452 Bcl-2 Apoptosis regulator proteins, Bcl-2 family
MOD_CDK_SPxxK_3 PF00069 Pkinase Protein kinase domain
MOD_CDK_SPK_2 PF00069 Pkinase Protein kinase domain
DOC_MAPK_MEF2A_6 PF00069 Pkinase Protein kinase domain
DOC_MAPK_DCC_7 PF00069 Pkinase Protein kinase domain
DOC_MAPK_HePTP_8 PF00069 Pkinase Protein kinase domain
LIG_APCC_ABBA_1 PF00400 WD40 WD domain, G-beta repeat
LIG_APCC_ABBAyCdc20_2 PF00400 WD40 WD domain, G-beta repeat
DOC_MAPK_GRA24_9 PF00069 Pkinase Protein kinase domain
LIG_IRF3_LxIS_1 PF10401 IRF-3 Interferon-regulatory factor 3
LIG_14-3-3_ChREBP_3 PF00244 14-3-3 14-3-3 protein
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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