COVID-19 SLiM Links
HSTalks interview Gibson and Yamauchi on SARS-CoV-2 entry SLiMs
Our article on SLiM signatures in the SARS-CoV-2 entry system is now available at Science Signaling
Validation experiments for SARS-CoV-2 entry system SLiMs
SPIKE CendR and NRP1 Receptor in SARS-CoV-2 cell entry
- ELM database updates
In a huge update, nine new ELM classes
DEG_Cend_DCAF12_1
DEG_Cend_KLHDC2_1
DOC_CYCLIN_RevRxL_6
DOC_PUB_PIM_1
LIG_CtBP_RRT_2
LIG_SH3_PxxxRxxKP_6
LIG_SH3_PxRPPK_7
LIG_SH3_PxxPPRxxK_8
LIG_RBL1_LxSxE_2
have been released. Further, five classes
DOC_PP2B_LxvP_1
DOC_PP2B_PxIxIT_1
LIG_RB_LxCxE_1
LIG_RB_pABgroove_1
LIG_SH3_PxxDY_5
have been substantially revised with ~70 new instances.
- ELM database updates
In this release, three new classes LIG_TRAF3_MATH_PxP_3, LIG_MSH2_SHIPbox_1 and MOD_AAK1BIKe_LxxQxTG_1 have been added. Also, two existing TRAF classes have been comprehensively revised - LIG_TRAF2like_MATH_shPxQ_1 (previously LIG_TRAF2_1) and LIG_TRAF2like_MATH_loPxQ_2 (previously LIG_TRAF2_2).
- ELM database updates
In a major addition seven new classes DEG_Cend_TRIM7_1, DEG_Cend_FEM1B_2, DEG_Cend_FEM1AC_1, LIG_Trf4_IWRxY_1, LIG_MTR4_AIM_1, LIG_IRF7_LxLS_2 and LIG_FERM_MyoX_1 have been added. Three classes, LIG_Nrd1CID_NIM_1, LIG_IRFs_LxIS_1 and LIG_SH2_NCK_1 have been updated.
- ELM database updates
Three new ELM classes LIG_ARS2_EDGEI_1, MOD_LOK_YxT_1 and TRG_NESrev_CRM1_2 have been added. MOD_PIKK_1 has been updated with 18 new instances.
- ELM database updates
Two new classes DEG_CRBN_cyclicCter_1 and TRG_Oom_RxLR_1 have been added to the database.
- ELM database updates
Protein degradation systems got more coverage in ELM. Four new classes LIG_VCP_SHPBox_1, LIG_VCP_VIM_2, LIG_VCP_VBM_3 and DEG_Kelch_KLHL12_1 added in database. In addition, several new instances have been added to DEG_APCC_DBOX_1 entry.
- ELM database updates
ELM now includes more Synapse proteins. New classes LIG_Arc_Nlobe_1 has been added. LIG_CaMK_CASK_1 has been substantially revised and updated to include the latest knowledge.
- ELM database updates
ELM classes MOD_NEK2_1 and MOD_NEK2_2 have been revised and updated to represent stricter and tolerant NEK2 site motif preferences, respectively.
- ELM database updates
Two new classes LIG_LEDGF_IBM_1 and LIG_Menin_MBM1_1 have been added to the database.
- ELM database updates
One new class LIG_TRAF4_MATH_1 added to the database. LIG_TRAF6 has been changed to LIG_TRAF6_MATH_1, the motif has been revised and several new instances added.
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The ELM phosphorylation DB
The Switches.ELM DB
Download a movie about a molecular switch involved in the formation of the ALG2/Alix complex
Functional site prediction |
Disclaimer
Short patterns applied to proteins are usually not statistically significant: Therefore we can't provide E-values as with BLAST searches. This means that most matches shown are more likely to be false positives than true matches. We hope that ELM server results will prove useful as guides to experimentation but they should not be treated as factual findings.
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement