SEARCH the ELM database

The ELM relational database stores different types of data about experimentally validated SLiMs that are manually curated from the literature. ELM instances are classified by motif type, functional site and ELM class. A functional site contains one to many ELM classes, which are described by a regular expression and list experimentally validated motif instances matching this sequence pattern. All data curated in ELM DB can be searched on the ELM website according to the following categories:

• 319 annotated ELM classes
• 3,963 experimentally validated ELM instances in 263 taxons
• 143 ELM methods described in 3,918 articles to experimentally validate ELM instances
• 630 solved PDB structures for curated ELM instances (from PDB)
• 162 globular ELM binding domains (from Pfam, SMART, and InterPro)
• 2,429 interactions mediated by curated ELM instances
• 887 regulatory switches mediated by curated ELM instances (from Switches.ELM DB)
• 1,063 pathways from KEGG involving linear motifs annotated in 1297 Sequences
• 280 viral instances interfering with host cellular processes
• 11 ELM related diseases annotated as being caused by aberrant motif function
• 2 examples where pathogens abuse motifs to deregulate host cells