COVID-19 SLiM Links
HSTalks interview Gibson and Yamauchi on SARS-CoV-2 entry SLiMs
Our article on SLiM signatures in the SARS-CoV-2 entry system is now available at Science Signaling
Validation experiments for SARS-CoV-2 entry system SLiMs
SPIKE CendR and NRP1 Receptor in SARS-CoV-2 cell entry
- ELM database updates
In this release, three new classes LIG_TRAF3_MATH_PxP_3, LIG_MSH2_SHIPbox_1 and MOD_AAK1BIKe_LxxQxTG_1 have been added. Also, two existing TRAF classes have been comprehensively revised - LIG_TRAF2like_MATH_shPxQ_1 (previously LIG_TRAF2_1) and LIG_TRAF2like_MATH_loPxQ_2 (previously LIG_TRAF2_2).
- ELM database updates
In a major addition seven new classes DEG_Cend_TRIM7_1, DEG_Cend_FEM1B_2, DEG_Cend_FEM1AC_1, LIG_Trf4_IWRxY_1, LIG_MTR4_AIM_1, LIG_IRF7_LxLS_2 and LIG_FERM_MyoX_1 have been added. Three classes, LIG_Nrd1CID_NIM_1, LIG_IRFs_LxIS_1 and LIG_SH2_NCK_1 have been updated.
- ELM database updates
Three new ELM classes LIG_ARS2_EDGEI_1, MOD_LOK_YxT_1 and TRG_NESrev_CRM1_2 have been added. MOD_PIKK_1 has been updated with 18 new instances.
- ELM database updates
Two new classes DEG_CRBN_cyclicCter_1 and TRG_Oom_RxLR_1 have been added to the database.
- ELM database updates
Protein degradation systems got more coverage in ELM. Four new classes LIG_VCP_SHPBox_1, LIG_VCP_VIM_2, LIG_VCP_VBM_3 and DEG_Kelch_KLHL12_1 added in database. In addition, several new instances have been added to DEG_APCC_DBOX_1 entry.
- ELM database updates
ELM now includes more Synapse proteins. New classes LIG_Arc_Nlobe_1 has been added. LIG_CaMK_CASK_1 has been substantially revised and updated to include the latest knowledge.
- ELM database updates
ELM classes MOD_NEK2_1 and MOD_NEK2_2 have been revised and updated to represent stricter and tolerant NEK2 site motif preferences, respectively.
- ELM database updates
Two new classes LIG_LEDGF_IBM_1 and LIG_Menin_MBM1_1 have been added to the database.
- ELM database updates
One new class LIG_TRAF4_MATH_1 added to the database. LIG_TRAF6 has been changed to LIG_TRAF6_MATH_1, the motif has been revised and several new instances added.
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The ELM phosphorylation DB
The Switches.ELM DB
Download a movie about a molecular switch involved in the formation of the ALG2/Alix complex
SEARCH the ELM database
The ELM relational database stores different types of data about experimentally validated SLiMs that are manually curated from the literature. ELM instances are classified by motif type, functional site and ELM class. A functional site contains one to many ELM classes, which are described by a regular expression and list experimentally validated motif instances matching this sequence pattern. All data curated in ELM DB can be searched on the ELM website according to the following categories:
- 340 annotated ELM classes
- 4,138 experimentally validated ELM instances in 270 taxons
- 144 ELM methods described in 4,136 articles to experimentally validate ELM instances
- 674 solved PDB structures for curated ELM instances (from PDB)
- 178 globular ELM binding domains (from Pfam, SMART, and InterPro)
- 2,570 interactions mediated by curated ELM instances
- 887 regulatory switches mediated by curated ELM instances (from Switches.ELM DB)
- 1,063 pathways from KEGG involving linear motifs annotated in 1297 Sequences
- 285 viral instances interfering with host cellular processes
- 11 ELM related diseases annotated as being caused by aberrant motif function
- 2 examples where pathogens abuse motifs to deregulate host cells
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement