DEG_Kelch_actinfilin_1

Regulation of certain glutamate receptors, scaffolds and signaling proteins are mediated by their proper degradation by kelch domain (PF01344) containing proteins. Actinfilin (Q6TDP4) is a kelch domain containing protein largely enriched in brain especially in cerebrum and cerebellum and is present in postsynaptic density. It plays a key role in actin polymerization, stability, subcellular anchoring and in actin-based neuronal function (Chen,2002). The actinfilin protein contains two functional domains that mediate protein degradation, a BTB domain (PF00651) that binds Cul3-based ligases, and a Kelch domain that interacts with the substrate. The kainate receptor GluR6 (Q13002) binds to the kelch domain of actinfilin through a hydrophobic motif and this interaction is important for the correct regulation of GluR6 surface expression (Salinas,2006).