The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
Immunoreceptor tyrosine-based motif
Functional site description:
In the cytoplasmatic region of immunoreceptors there are motifs that are critical for the activation and termination of signal transduction pathways.
ELMs with same func. site: LIG_TYR_ITAM  LIG_TYR_ITIM  LIG_TYR_ITSM 
ELM Description:
ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase.
Pattern: [ILV].(Y)..[ILV]
Pattern Probability: 0.0002992
Present in taxon: Vertebrata
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
o See 7 Instances for LIG_TYR_ITIM
o Abstract
Antigen recognition and communication among cells (T, B and natural killer cells) of the immune system are regulated at the level of cell-surface antigen and transmembrane receptors. The extracellular regions of these receptors provide the immune specificity, whereas the intracellular region interacts with cytoplasmatic signaling molecules that are critical for the activation and termination of signal transduction pathways. The initial signaling events following the engagement of antigen receptors are regulated by the phosphorylation of characteristic signaling motifs that coordinate the activity of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPases), and thus regulate the activation or inhibition of the intracellular response. Some receptors like CD154, CD28, CD3 transmit mainly positive co-stimulatory signals, whereas others, such as CTLA-4 killer inhibitory receptors (KIRs) or leukocyte immunoglobulin-like receptors (LIRs), function principally as inhibitory receptors. In addition, a group of dual-function receptors, such as the CD150 subfamily within the CD2 family, can either act as positive or negative regulators.
o 3 selected references:

o 2 GO-Terms:

o 7 Instances for LIG_TYR_ITIM
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q91Y57 Siglec12
430 435 PSSTEEEIHYATLSFHEMKP TP 3 Mus musculus (House mouse)
279 284 VLVCSKPVTYATVIFPGGNK TP 2 Homo sapiens (Human)
O43613 HCRTR1
356 361 ANSAANPIIYNFLSGKFREQ TP 3 Homo sapiens (Human)
P26715 KLRC1
38 43 ILATEQEITYAELNLQKASQ TP 0 Homo sapiens (Human)
P43630 KIR3DL2
396 401 DEQDPQEVTYAQLDHCVFIQ TP 1 Homo sapiens (Human)
P31994 FCGR2B
290 295 KVGAENTITYSLLMHPDALE TP 2 Homo sapiens (Human)
P08101 Fcgr2
307 312 KTEAENTITYSLLKHPEALD TP 1 Mus musculus (House mouse)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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