The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
Functional site description:
PTS2 is a signal placed toward the N-terminus of some proteins that are directed to the peroxisomal matrix
ELMs with same tags:
ELM Description:
Generic PTS2 pattern for all eukaryotes (except lineages which have lost it)
Pattern: ^.{1,40}R[^P][^P][^P][LIV][^P][^P][HQ][LIF]
Pattern Probability: 0.0000039
Present in taxon: Eukaryota
Not represented in taxon: Caenorhabditis elegans
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
PDB Structure: 1EPX
o See 2 Instances for TRG_PTS2
o Abstract
PTS2, peroxisomal targeting signal 2, is one of two peroxisomal import signals which direct proteins into the lumen (matrix) of the peroxisome.
(The other being PTS1.) A third signal is used to target peroxisomal membrane proteins. PTS2 is found less often than PTS1 and has been lost in
the lineage leading to Ceanorhabditis elegans (and perhaps other nematodes too).
o 6 GO-Terms:

o 2 Instances for TRG_PTS2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q9U5N6 ald
1 11 MSRVTVLQSQLPAYNRLKTP TP 1 Leishmania mexicana
P07752 ALD
1 12 MSKRVEVLLTQLPAYNRLKT TP 1 Trypanosoma brucei brucei
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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