The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
WH1 ligand
Functional site description:
The WH1 domain ligand found in WIP (WASP-interacting protein) binds the WH1 domain of WASP and N-WASP proteins.
ELM Description:
LIG_WH1 is the WIP sequence motif binding to the WH1 domains of WASP and N-WASP.
Pattern: ES[RK][FY].F[HR][PST][IVLM][DES][DE]
Pattern Probability: 8.900e-11
Present in taxons: Eukaryota Homo sapiens Saccharomyces cerevisiae
Interaction Domain:
WH1 (PF00568) WH1 domain (Stochiometry: 1 : 1)
o See 3 Instances for LIG_WH1
o Abstract
Wiskott-Aldrich syndrome protein (WASP) and WASP-interacting protein (WIP) form a complex that has a pivotal function in integrating sigalling cascades that lead to acting polymerization. The WASP-binding domain (WBD) in WIP is known to bind to the WH1 (WASP homology 1) domain of WASP and N-WASP. The strong sequence conservation between the WH1 and the EVH1 domains, including the residues involved in coordinating EVH1 binding to FPPPP ligands, suggested that the WH1 domain may also bind a prolin-rich ligand. Indeed, the WBD in WIP consists of 26% proline residues and contains four proline sequence motifs, one of which is closely related to the WASP EVH1-binding motif. However it was found that WH1 and EVH1 domains bind distinct sequence motifs. The N-WASP WH1-binding motif of WIP is highly conserved also in the mammalian WIP homologs CR16 and WICH, two proteins interacting with N-WASP.
o 1 selected reference:

o 9 GO-Terms:

o 3 Instances for LIG_WH1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
420 430 IDDFESKFTFHSVEDFPPPD TP 2 Homo sapiens (Human)
397 407 LDDFESKYSFHPVEDFPAPE TP 2 Homo sapiens (Human)
O43516 WIPF1
451 461 EDEWESRFYFHPISDLPPPE TP 3 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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