The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
 «LIG_WRPW_1«   »LIG_WW_1» 

LIG_WRPW_2

Accession:
Functional site class:
WRPW motif
Functional site description:
The WRPW motif mediates co-repressor recruitment.
ELMs with same func. site: LIG_WRPW_1  LIG_WRPW_2 
ELM Description:
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1).
Pattern: [WFY][KR]P[WFY]
Pattern Probability: 0.0000182
Present in taxon: Eumetazoa
Interaction Domain:
WD40 (PF00400) WD domain, G-beta repeat (Stochiometry: 1 : 1)
o See 2 Instances for LIG_WRPW_2
o Abstract
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (Paroush,1994; Fisher,1996; Grbavec,1996; Courey,2001). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho-binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus (Goldstein,1999), and FKPY in Brinker (Drosophila) (Zhang,2001).
o 2 selected references:

o 3 GO-Terms:

o 2 Instances for LIG_WRPW_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q9XTN4 brk
Q9XTN4_DROME 		461 464 LPSKQVKLFKPYLLDDDEEQ TP 3 Drosophila melanogaster (Fruit fly)
1 
Q9VN10 hkb
Q9VN10_DROME 		16 19 PPQTYSRLFRPWDTQRQAAT TP 4 Drosophila melanogaster (Fruit fly)
1 
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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