The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
HP1 ligand
Functional site description:
Motif in proteins that interact with the chromoshadow domain of Heterochromatin-binding protein 1.
ELM Description:
Motif is a ligand to an interface formed by dimerization of two chromoshadow domains in HP1 proteins.
Pattern Probability: 0.0000338
Present in taxon: Eukaryota
Interaction Domain:
Chromo_shadow (PF01393) Chromo shadow domain (Stochiometry: 1 : 1)
PDB Structure: 1S4Z
o See 9 Instances for LIG_HP1_1
o Abstract
HP1 is a nonhistone chromosomal protein primarily associated with heterochromatin. In mammals three variants exist: HP1 alpha, HP1 beta and HP1 gamma. All have an N-terminal chromodomain (SM00298) and a C-terminal chromoshadow domain (SM00300). The HP1 chromodomain can bind to metylated lysine 9 on histone H3, while the chromoshadow domain can mediate homo-dimerisation and interaction with other proteins. The PxVxL motif was identified as a HP1-binding motif by Smothers,2000). Several chromatin modifying proteins have been shown to interact with HP1 using this motif. Structural analysis has shown that the motif interacts with a chomoshadow domain dimer (Brasher,2000).
o 4 selected references:

o 5 GO-Terms:

o 9 Instances for LIG_HP1_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
Q62318 Trim28
486 490 SGLLRKVPRVSLERLDLDLT TP 4 Mus musculus (House mouse)
Q13263 TRIM28
486 490 SGLMRKVPRVSLERLDLDLT TP 6 Homo sapiens (Human)
Q9QWF0 Chaf1a
222 226 LLFIEKVPVVVLEDILATKP TP 1 Mus musculus (House mouse)
P20193 Su(var)3-7
394 398 PEDAQDTPVVMMNGDVDSGD TP 1 Drosophila melanogaster (Fruit fly)
O00268 TAF4
764 768 QVTLTQTPMVALRQPHNRIM TP 1 Homo sapiens (Human)
O15164 TRIM24
713 717 ADSTHKVPVVMLEPIRIKQE TP 2 Homo sapiens (Human)
Q9VI63 Alh
1051 1055 AVPATTSPLVVLSNQLPLNS TP 2 Drosophila melanogaster (Fruit fly)
P12956 XRCC6
352 356 LMLMGFKPLVLLKKHHYLRP TP 2 Homo sapiens (Human)
Q13111 CHAF1A
238 242 ILFKGKVPMVVLQDILAVRP TP 1 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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