Accession: | |
---|---|
Functional site class: | SID |
Functional site description: | Sin3 interacting domain |
ELMs with same func. site: | LIG_Sin3_1 LIG_Sin3_2 LIG_Sin3_3 |
ELM Description: | Motif interacts with PAH2 domain in the Sin3 scaffold protein (sp-1 like). |
Pattern: | [FHYM].A[AV].[VAC]L[MV].[MI] |
Pattern Probability: | 1.937e-08 |
Present in taxon: | Eukaryota |
Interaction Domain: |
PAH (PF02671)
Paired amphipathic helix repeat
(Stochiometry: 1 : 1)
|
Abstract |
Gene-specific targeting of the Sin3 co-repressor complex by DNA-bound repressors is an important mechanism of gene silencing in eukaryotes. The Sin3 co-repressor is a scaffold protein able to interact with several proteins simultaneously. Sin3 specifically interacts with a diverse set of transcriptional repressors, the first of which were identified as the MAD-family members. Sin3 contains paired amphipatic helix repeat domains (PAH) that mediate protein-protein interactions. In addition, Sin3 has a histone deacetylase binding site. The SID (Sin3 interacting domain) motif specifically interacts with the PAH2 domain in Sin3. In humans, the Sin3 protein has two splice isoforms: mSin3A and mSinB. Both have the PAH2 domain and can interact with a SID-containing protein. The structure of the PAH2:MAD1 interaction has been solved (1G1E) (Brubaker,2000). The SID helix is an amphiphatic alpha helix that engages in substantial hydrophobic interactions with a deep hydrophobic groove defined by two PAH2 helices. Presumably all SID-containing proteins are targeted to a DNA region either by direct DNA binding or interaction with a DNA-binding partner, and recruit the Sin3-complex, which ultimately leads to deacetylation and repression of transcription. |
3 Instances for LIG_Sin3_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, Name | Start | End | Subsequence | Logic | #Ev. | Organism | Notes |
---|---|---|---|---|---|---|---|
Q9Y2Y9 KLF13 KLF13_HUMAN |
9 | 18 | AAYVDHFAAECLVSMSSRAV | TP | 1 | Homo sapiens (Human) | |
O14901 KLF11 KLF11_HUMAN |
45 | 54 | LEQTDMEAVEALVCMSSWGQ | TP | 2 | Homo sapiens (Human) | |
Q13118 KLF10 KLF10_HUMAN |
39 | 48 | AEKSDFEAVEALMSMSCSWK | TP | 2 | Homo sapiens (Human) |
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement