The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
PCSK cleavage site
Functional site description:
The subtilisin-like proprotein convertases are expressed extensively in mammalian neural and endocrine cells and play a major role in the proteolytic processing of both neuropeptide and peptide hormone precursors.
ELMs with same func. site: CLV_PCSK_FUR_1  CLV_PCSK_KEX2_1  CLV_PCSK_PC1ET2_1  CLV_PCSK_PC7_1  CLV_PCSK_SKI1_1 
ELM Description:
NEC1/NEC2 cleavage site (K-R-|-X).
Pattern: KR.
Pattern Probability: 0.0039028
Present in taxon: Vertebrata
Interaction Domain:
Peptidase_S8 (PF00082) Subtilase family (Stochiometry: 1 : 1)
o See 6 Instances for CLV_PCSK_PC1ET2_1
o Abstract
The members of the subtilisin-like family are proprotein convertases that process latent precursor proteins into their biologically active products. The prohormone-processing yeast KEX2 protease can act as an intracellular membrane protein or a soluble, secreted endopeptidase. The protein is required for processing of precursors of alpha-factor and killer toxin. PCSK1 (proprotein convertase 1, NEC1) and PCSK2 (proprotein convertase 2, NEC2) are type I proinsulin-processing enzymes that play a key role in regulating insulin biosynthesis. They are also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. PACE4 (paired basic amino acid cleaving system 4, SPC4) is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Its substrates include transforming growth factor beta-related proteins, proalbumin, and von Willebrand factor. Furin (PACE, paired basic amino acid cleaving enzyme, membrane associated receptor protein) is serine endoprotease responsible for processing a variety of substrates (proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor). PC7 (proprotein convertase subtilisin/kexin type 7) is closely related to PACE and PACE4. This calcium-dependent serine endoprotease is concentrated in the trans-Golgi network, associated with membranes, and is not secreted. It can process proalbumin. PC7 and furin are also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140.
o 4 selected references:

o 6 GO-Terms:

o 6 Instances for CLV_PCSK_PC1ET2_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P01193 Pomc
203 205 RWSNPPKDKRYGGFMTSEKS TP 3 Mus musculus (House mouse)
P01193 Pomc
122 124 PEPSPREGKRSYSMEHFRWG TP 3 Mus musculus (House mouse)
P01193 Pomc
163 165 AEAFPLEFKRELEGERPLGL TP 3 Mus musculus (House mouse)
P00796 Ren2
62 64 SAEWDVFTKRSSLTDLISPV TP 3 Mus musculus (House mouse)
P00797 REN
65 67 GPEWSQPMKRLTLGNTTSSV TP 6 Homo sapiens (Human)
P06300 Pdyn
164 166 EEDLRKQAKRYGGFLRKYPK TP 3 Rattus norvegicus (Norway rat)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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