The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Accession:
Functional site class:
N-glycosylation site
Functional site description:
N-linked glycosylation is a co-translational process involving the transfer of a oligosaccharide chain to asparagine residue in the protein.
ELMs with same func. site: MOD_N-GLC_1  MOD_N-GLC_2 
ELM Description:
Atipical motif for N-glycosylation site. Examples are Human CD69, which is uniquely glycosylated at typical (Asn-X-Ser/Thr) and atypical (Asn-X-Cys) motifs, beta protein C
Pattern: (N)[^P]C
Pattern Probability: 0.0002973
Present in taxon: Vertebrata
Interaction Domain:
STT3 (PF02516) Oligosaccharyl transferase STT3 subunit (Stochiometry: 1 : 1)
o See 5 Instances for MOD_N-GLC_2
o Abstract
N-glycosylation is the most common modification of secretory and membrane-bound proteins in eukaryotic cells. The whole process of N-glycosylation comprises more than 100 enzymes and transport proteins. The biosynthesis of all N-linked oligosaccharides begins in the ER with a large precursor oligosaccharid. The structure of this oligosaccharide [(Glc)3(Man)9(GlcNAc)2] is the same in plants, animals, and single cell eukaryotes. This precursor is linked to a dolichol, a long-chain polyisoprenoid lipid that act as a carrier for the oligosaccharide. The oligosaccharide is then transferred by an ER enzyme from the dodichol carrier to an asparagine residue on a nascent protein. The oligosaccharide chain is then processed as the glycoprotein moves through the Golgi apparatus. In some cases this modification involves attachment of more mannose groups, in other cases a more complex type of structure is attached.
o 2 selected references:

o 7 GO-Terms:

o 5 Instances for MOD_N-GLC_2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P04275 VWF
VWF_HUMAN
1147 1149 GYECEWRYNSCAPACQVTCQ TP 1 Homo sapiens (Human)
Q07108 CD69
CD69_HUMAN
111 113 KRSWTSAQNACSEHGATLAV TP 1 Homo sapiens (Human)
P00533 EGFR
EGFR_HUMAN
56 58 FLSLQRMFNNCEVVLGNLEI TP 1 Homo sapiens (Human)
P00745 PROC
PROC_BOVIN
366 368 KVPVVPYNACVHAMENKISE TP 1 Bos taurus (Cattle)
P04070 PROC
PROC_HUMAN
371 373 IKIPVVPHNECSEVMSNMVS TP 1 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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