| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001919 | Q05655 PRKCD KPCD_HUMAN |
326 | 330 | KTGVAGEDMQDNSGTYGKIW | TP | --- | Homo sapiens (Human) | 676 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0113 | western blot | in vitro | Emoto,1995 | support | likely | ParticipantIdentification FeatureDetection |
| experimental | MI:0039 | edman degradation | in vitro | Emoto,1995 | support | likely | ParticipantIdentification |
| experimental | MI:0194 | cleavage reaction | in vivo/in vitro | Emoto,1995 | support | likely | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P42574) CASP3_HUMAN | PF00656
(Peptidase_C14)
Caspase domain |
45 | 275 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000493:
Alternative splicing inserts exons within the Caspase-3 scission motif of Protein kinase C delta type (PRKCD), abrogating binding to Caspase-3 (CASP3). Cleavage of PKCdeltaI Protein kinase C delta type (PRKCD) by caspase-3 releases a catalytically active C-terminal fragment that is sufficient to induce apoptosis. This inserted exon disrupts scission motifs and therefore the PKCdeltaVIII (GENBANK:DQ516383) splice variant functions as an anti-apoptotic protein in NT2 cells.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- Autophagy animal
- C type lectin receptor signaling pathway
- Chemical carcinogenesis reactive oxygen species
- Chemokine signaling pathway
- Diabetic cardiomyopathy
- Estrogen signaling pathway
- Fc gamma R mediated phagocytosis
- GnRH signaling pathway
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- NOD like receptor signaling pathway
- Neurotrophin signaling pathway
- Prion disease
- Shigellosis
- Type II diabetes mellitus
- Vascular smooth muscle contraction
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement