The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
29 34 EEADSPSDSGQGSYETIGPL TP --- Homo sapiens (Human) 1339

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Peschiaroli,2006 support certain FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Peschiaroli,2006 support certain InteractionDetection
experimental MI:0054 fluorescence-activated cell sorting in vivo Peschiaroli,2006 support certain InteractionDetection

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000168:
    ELM Switch SWTI000168

    Dual phosphorylation of S30 and S34 in the TrCP1-binding motif of Claspin (CLSPN) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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