| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI003034 | P32418 SLC8A1 NAC1_HUMAN |
388 | 394 | HAADQARKAVSMHEVNTEVT | TP | --- | Homo sapiens (Human) | 973 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Pulina,2006 | support | certain | FeatureDetection |
| experimental | MI:0096 | pull down | in vivo/in vitro | Pulina,2006 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000110:
Phosphorylation of S392 in the 14-3-3-binding motif of Sodium/calcium exchanger 1 (SLC8A1) induces binding to the 14-3-3 protein epsilon (YWHAE) protein. This interaction inhibits the activity of Sodium/calcium exchanger 1 (SLC8A1).
-
SWTI000110:
Phosphorylation of S392 in the 14-3-3-binding motif of Sodium/calcium exchanger 1 (SLC8A1) induces binding to the 14-3-3 protein epsilon (YWHAE) protein. This interaction inhibits the activity of Sodium/calcium exchanger 1 (SLC8A1).
Pathways
- Adrenergic signaling in cardiomyocytes
- Apelin signaling pathway
- Arrhythmogenic right ventricular cardiomyopathy
- Calcium signaling pathway
- Cardiac muscle contraction
- Dilated cardiomyopathy
- Endocrine and other factor regulated calcium reabsorption
- Hypertrophic cardiomyopathy
- Mineral absorption
- Olfactory transduction
- Protein digestion and absorption
- cGMP PKG signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement