ELM - instance LIG_14-3-3_CanoR_1 in sequence P98177 at position 29

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002988	P98177 FOXO4 FOXO4_HUMAN	29	34	FEPQSRPRSCTWPLPRPEIA	TP	---	Homo sapiens (Human)	505

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0027	cosedimentation	in vitro	Obsil,2003	support	certain	InteractionDetection
experimental	MI:0071	molecular sieving	in vivo/in vitro	Obsil,2003	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Obsil,2003	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000690:

Phosphorylation of two 14-3-3-binding motifs in Foxo4 by PKB induces binding of 14-3-3 dimer. In the nucleus, this blocks binding to DNA, while in the cytoplasm it blocks reimport of Foxo4 into the nucleus by blocking its Nuclear Localisation Signal (NLS). Since binding of 14-3-3 to a single motif occurs with an affinity similar to the affinity of Foxo4 for DNA, multivalent binding of 14-3-3 dimer is required for efficient inhibition of DNA binding.

Pathways

KEGG: The sequence P98177 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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