| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002997 | Q61337 Bad BAD_MOUSE |
133 | 138 | ELSPFRGRSRSAPPNLWAAQ | TP | --- | Mus musculus (House mouse) | 204 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0007 | anti tag coimmunoprecipitation | in vivo | Datta,2000 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Datta,2000 | support | certain | FeatureDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Zha,1996 | support | certain | FeatureDetection |
| experimental | MI:0007 | anti tag coimmunoprecipitation | in vivo | Zha,1996 | support | certain | InteractionDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Zha,1996 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000697:
Phosphorylation of S136 in Bcl2 antagonist of cell death (Bad) by RAC-alpha serine/threonine-protein kinase (Akt1) in response to survival and growth signals such as Interleukin-3 (Il3) induces binding to 14-3-3 protein theta (Ywhaq). Binding of 14-3-3 protein theta (Ywhaq) results in dissociation of Bcl2 antagonist of cell death (Bad) from Bcl-2-like protein 1 (Bcl2l1), and thereby inhibits the pro-apoptotic activity of Bcl2 antagonist of cell death (Bad) by allowing liberated Bcl-2-like protein 1 (Bcl2l1) to exert its anti-apoptotic effect on pro-apoptotic proteins like Apoptosis regulator BAX (Bax).
Pathways
- Acute myeloid leukemia
- Alzheimer disease
- Amyotrophic lateral sclerosis
- Apoptosis
- Autophagy animal
- Chemical carcinogenesis reactive oxygen species
- Chemical carcinogenesis receptor activation
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin signaling pathway
- Lipid and atherosclerosis
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Non small cell lung cancer
- PI3K Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Pathways of neurodegeneration multiple diseases
- Platinum drug resistance
- Prion disease
- Prostate cancer
- Ras signaling pathway
- Renal cell carcinoma
- Thyroid hormone signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Viral carcinogenesis
- cAMP signaling pathway
- cGMP PKG signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement