| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI003004 | Q99683 MAP3K5 M3K5_HUMAN |
963 | 968 | AGSNEYLRSISLPVPVLVED | TP |
2BR9 |
Homo sapiens (Human) | 1374 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0114 | x-ray crystallography | in vitro | Yang,2006 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Zhang,1999 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000108:
Phosphorylation of S966 in the 14-3-3-binding motif of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) induces binding to the 14-3-3 protein zeta/delta (YWHAZ) protein. This interaction inhibits the pro-apoptotic activity of Mitogen-activated protein kinase kinase kinase 5 (MAP3K5).
Pathways
Please cite:
The eukaryotic linear motif resource - 2018 update.
(PMID:29136216)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement