ELM - instance LIG_EVH1_2 in sequence P23385 at position 1152

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001696	P23385 Grm1 GRM1_RAT	1152	1156	EDSPALTPPSPFRDSVASGS	TP	---	Rattus norvegicus (Norway rat)	1199

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Beneken,2000	support	certain
predicted	MI:0114	x-ray crystallography	in vitro	Tu,1998	support	certain	InteractionDetection FeatureDetection
experimental	MI:0113	western blot	in vitro	Beneken,2000	support	certain	ParticipantIdentification FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Beneken,2000	support	certain	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q9Z214) HOME1_RAT	PF00568 (WH1) WH1 domain	1	107		[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000496:

Alternative splicing removes the EVH1-binding motif of Metabotropic glutamate receptor 1 (Grm1), abrogating binding to Homer protein homolog 1 (Homer1), which is important for spatial targeting of Grm1.

Pathways

KEGG: The sequence P23385 is implicated in the following 13 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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