ELM - instance LIG_PDZ_Class_2 in sequence P49768 at position 462

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002184	P49768 PSEN1 PSN1_HUMAN	462	467	ATDYLVQPFMDQLAFHQFYI	TP	---	Homo sapiens (Human)	467

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0018	two hybrid	in vivo	Xu,2000	support	certain	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Lau,2000	support	certain
experimental	MI:0429	necessary binding site		Lau,2000	support	certain
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Lau,2000	support	certain	InteractionDetection
experimental	MI:0096	pull down	in vivo/in vitro	Lau,2000	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000327:

An intramolecular interaction of the C-terminal PDZ binding motif of Amyloid beta A4 precursor protein-binding family A member 1 (APBA1) (also known as X11alpha/Mint1) with the PDZ domain tandem of APBA1 results in an auto-inhibited conformation of APBA1, where binding of ligands containing a PDZ binding motif such as Presenilin-1 (PSEN1) is blocked. Binding of these ligands might be regulated by phosphorylation of Y836 in the APBA1 PDZ-binding motif, as its mutation to glutamate releases autoinhibition and enhances the interaction of the APBA1 PDZ tandem with presenilin.

Pathways

KEGG: The sequence P49768 is implicated in the following 6 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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