| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001564 | P01130 LDLR LDLR_HUMAN |
822 | 829 | KNINSINFDNPVYQKTTEDE | TP | --- | Homo sapiens (Human) | 860 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Trommsdorff,1998 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Trommsdorff,1998 | support | certain | InteractionDetection |
| experimental | MI:0018 | two hybrid | in vivo | Trommsdorff,1998 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (O75553) DAB1_HUMAN | PF00640
(PID)
Phosphotyrosine interaction domain (PTB/PID) |
42 | 168 | [mitab][xml] |
Pathways
- Aldosterone synthesis and secretion
- Bile secretion
- Cholesterol metabolism
- Cortisol synthesis and secretion
- Cushing syndrome
- Endocytosis
- Hepatitis C
- Lipid and atherosclerosis
- Ovarian steroidogenesis
- Toxoplasmosis
Diseases
- Sequence Variation VAR_062383 (Pos 826) has been implicated in Hypercholesterolemia, Familial (OMIM:143890).
- Sequence Variation VAR_005419 (Pos 828) has been implicated in Hypercholesterolemia, Familial (OMIM:143890).
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement