The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
LIG_RB_pABgroove_1

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004828 O00716 E2F3
E2F3_HUMAN 		442 450 SLGEEEGISDLFDAYDLEKL TP --- Homo sapiens (Human) 465

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0065 isothermal titration calorimetry in vitro Liban,2016 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P06400) RB_HUMAN IPR002720 (Retinoblastoma-associated protein A-box)
Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation 		373 573 1.2/1.2 [mitab][xml]
(P06400) RB_HUMAN IPR002719 (Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno... 		646 765 [mitab][xml]
(P28749) RBL1_HUMAN IPR002720 (Retinoblastoma-associated protein A-box)
Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation 		385 578 7.0/7.0 [mitab][xml]
(P28749) RBL1_HUMAN IPR002719 (Retinoblastoma-associated protein, B-box)
This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno... 		787 943 [mitab][xml]

o  Pathways

KEGG: The sequence O00716 is implicated in the following 23 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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