ELM - instance LIG_RB_pABgroove_1 in sequence Q16254 at position 400

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI004829	Q16254 E2F4 E2F4_HUMAN	400	408	YNLDESEGVCDLFDVPVLNL	TP	---	Homo sapiens (Human)	413

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Liban,2016	support	certain	FeatureDetection
experimental	MI:0065	isothermal titration calorimetry	in vitro	Liban,2016	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P06400) RB_HUMAN	IPR002720 (Retinoblastoma-associated protein A-box) Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation	373	573	0.5/0.5	[mitab][xml]
(P06400) RB_HUMAN	IPR002719 (Retinoblastoma-associated protein, B-box) This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno...	646	765		[mitab][xml]
(P28749) RBL1_HUMAN	IPR002720 (Retinoblastoma-associated protein A-box) Retinoblastoma-like and retinoblastoma-associated proteins may have a function in cell cycle regulation	385	578	0.15/0.15	[mitab][xml]
(P28749) RBL1_HUMAN	IPR002719 (Retinoblastoma-associated protein, B-box) This entry includes retinoblastoma-associated protein (RB, also known as pRb, RB, p1051), retinoblastoma-like protein 1 (RBL1, also known as p107) and retinoblastoma-like protein 2 (RBL2, also kno...	787	943		[mitab][xml]

Pathways

KEGG: The sequence Q16254 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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