| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI000386 | P10747 CD28 CD28_HUMAN |
191 | 194 | RSRLLHSDYMNMTPRRPGPT | TP |
3WA4 5GJH |
Homo sapiens (Human) | 220 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0065 | isothermal titration calorimetry | in vitro | Inaba,2017 | support | certain | InteractionDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Inaba,2017 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0114 | x-ray crystallography | in vitro | Higo,2013 | support | certain | InteractionDetection FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (O89100) GRAP2_MOUSE | PF00017
(SH2)
SH2 domain |
58 | 132 | [mitab][xml] | |
| (P62993) GRB2_HUMAN | PF00017
(SH2)
SH2 domain |
60 | 135 | [mitab][xml] |
Pathways
- Allograft rejection
- Autoimmune thyroid disease
- Cell adhesion molecules
- Graft versus host disease
- Intestinal immune network for IgA production
- Measles
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Rheumatoid arthritis
- Systemic lupus erythematosus
- T cell receptor signaling pathway
- Type I diabetes mellitus
- Viral myocarditis
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement