Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI002773 | P29590 PML PML_HUMAN |
555 | 566 | EAEERVVVISSSEDSDAENS | TP |
4WJN 4WJO |
Homo sapiens (Human) | 882 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Cappadocia,2015 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Shen,2006 | support | certain | FeatureDetection |
experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Shen,2006 | support | certain | InteractionDetection |
experimental | MI:0113 | western blot | in vitro | Shen,2006 | support | certain | ParticipantIdentification FeatureDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000707:
Alternative splicing removes the Sumoylation interacting motif (SIM) of Protein PML (PML), abrogating binding to Small ubiquitin-related modifier 1 (SUMO1) in Isoform TRIM19epsilon of Protein PML (PML). Isoforms lacking the SIM were resistant to As2O3-induced PML degradation.
-
SWTI000707:
Alternative splicing removes the Sumoylation interacting motif (SIM) of Protein PML (PML), abrogating binding to Small ubiquitin-related modifier 1 (SUMO1) in Isoform TRIM19epsilon of Protein PML (PML). Isoforms lacking the SIM were resistant to As2O3-induced PML degradation.
Pathways
KEGG: The sequence P29590 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement