Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001285 | P25054 APC APC_HUMAN |
2801 | 2811 | STSARPSQIPTPVNNNTKKR | TP | --- | Homo sapiens (Human) | 2843 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
experimental | MI:0519 | glutathione s tranferase tag | in vitro | Honnappa,2005 | support | certain | |
experimental | MI:0077 | nuclear magnetic resonance | in vitro | Honnappa,2005 | support | certain | InteractionDetection FeatureDetection |
experimental | MI:0017 | classical fluorescence spectroscopy | in vitro | Honnappa,2005 | support | certain | InteractionDetection |
experimental | MI:0065 | isothermal titration calorimetry | in vitro | Honnappa,2005 | support | certain | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Honnappa,2005 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000276:
Phosphorylation of S2789 and S2793 adjacent to the EBH-binding motif of Adenomatous polyposis coli protein (APC), by, respectively, gradually reduces the affinity of its interaction with Microtubule-associated protein RP/EB family member 1 (MAPRE1).
Pathways
Please cite:
ELM — the eukaryotic linear motif resource in 2020.
(PMID:31680160)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement