The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003221 P28352 Apex1
APEX1_MOUSE
229 236 KGNKKNAGFTPQERQGFGEL TP --- Mus musculus (House mouse) 317

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0113 western blot in vitro Huang,2010 support certain ParticipantIdentification FeatureDetection
experimental MI:0424 protein kinase assay in vivo Huang,2010 support certain InteractionDetection
experimental MI:0586 inhibitor Huang,2010 support certain
experimental MI:0424 protein kinase assay in vitro Huang,2010 support certain InteractionDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Huang,2010 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q00535) CDK5_HUMAN PF00069 (Pkinase)
Protein kinase domain
4 286 [mitab][xml]

o  Pathways

KEGG: The sequence P28352 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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