ELM - instance TRG_ENDOCYTIC_2 in sequence P04578 at position 712

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001840	P04578 env ENV_HV1H2	712	715	IVNRVRQGYSPLSFQTHLPT	TP	---	HIV-1 M:B_HXB2R	856

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Blot,2003	support	certain	FeatureDetection
experimental	MI:0054	fluorescence-activated cell sorting	in vivo	Berlioz-Torrent,1999	support	certain	InteractionDetection
experimental	MI:0113	western blot	in vitro	Berlioz-Torrent,1999	support	certain	ParticipantIdentification FeatureDetection
experimental	MI:0663	confocal microscopy	in vivo/in vitro	Berlioz-Torrent,1999	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Berlioz-Torrent,1999	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Berlioz-Torrent,1999	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000225:

Binding of 18348" target="_blank">1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to the AP-2 complex alpha, beta and mu subunits exposes a binding site on the AP-2 complex subunit mu (AP2M1) subunit for recruitment of Envelope glycoprotein gp160 (env) via an endocytosis motif.

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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