ELM - instance LIG_FHA_2 in sequence P18887 at position 521

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI000986	P18887 XRCC1 XRCC1_HUMAN	521	527	YAGSTDENTDSEEHQEPPDL	TP	---	Homo sapiens (Human)	633

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0053	fluorescence polarization spectroscopy	in vitro	Luo,2004	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Luo,2004	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 5 switching mechanisms annotated at the switches.ELM resource:

SWTI000273:

Two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
SWTI000343:

Hierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).
SWTI000130:

Phosphorylation of T523 in the FHA-binding motif of DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1) induces binding to the Aprataxin (APTX) protein.
SWTI000273:

Two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules interact with two FHA-binding motifs in DNA repair protein XRCC1 (XRCC1) upon phosphorylation of T519 and T523 in the motifs. Additional phosphorylation of S518 and S525 further increases the affinity of the interaction. S518 and T523 are consensus CK2 phosphorylation sites, T519 and S525 atypical.
SWTI000343:

Hierarchical cooperative binding of two Bifunctional polynucleotide phosphatase/kinase (PNKP) molecules to one DNA repair protein XRCC1 (XRCC1) molecule upon phosphorylation of a primary and secondary FHA-binding motif in DNA repair protein XRCC1 (XRCC1) by Casein kinase II subunit alpha (CSNK2A1).

Pathways

KEGG: The sequence P18887 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Base excision repair

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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