ELM - instance DEG_ODPH_VHL_1 in sequence Q9Y2N7 at position 490

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001222	Q9Y2N7 HIF3A HIF3A_HUMAN	490	502	LEMLAPYISMDDDFQLNASE	TP	---	Homo sapiens (Human)	669

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Maynard,2003	support	likely	InteractionDetection
experimental	MI:0101	sequence based prediction	in silico	Maynard,2003	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000026:

Hydroxylation of P492 in the VHL-binding motif of Hypoxia-inducible factor 3-alpha (HIF3A) induces binding to the Von Hippel-Lindau disease tumor suppressor (VHL) protein.
SWTI000581:

Alternative splicing removes the VHL-hydroxyproline-modified binding motif of Hypoxia-inducible factor 3-alpha (HIF3A), abrogating binding to Von Hippel-Lindau disease tumor suppressor (VHL). Other studies have shown that the HIF-3 alpha-4 splice variant (Isoform HIF-3alpha4) can act as a dominant negative form with tumour-suppressive activity (see Maynard et al. (2007) (here)).

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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