ELM - instance LIG_PCNA_PIPBox_1 in sequence Q15054 at position 456

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001231	Q15054 POLD3 DPOD3_HUMAN	456	465	TAALGKANRQVSITGFFQRK	TP	1U76 1VYJ	Homo sapiens (Human)	466

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0065	isothermal titration calorimetry	in vitro	Bruning,2004	support	certain	InteractionDetection
experimental	MI:0114	x-ray crystallography	in vitro	Bruning,2004	support	certain	InteractionDetection FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(P12004) PCNA_HUMAN	PF02747 (PCNA_C) Proliferating cell nuclear antigen, C-terminal domain	127	254	15.6/15.6	[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000679:

Phosphorylation of S458 in the PCNA-binding motif of DNA polymerase delta subunit 3 (POLD3) by cAMP subfamily reduces the affinity of binding to the Proliferating cell nuclear antigen (PCNA) and decreases the processivity of the polymerase complex.

Pathways

KEGG: The sequence Q15054 is implicated in the following 5 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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