ELM - instance TRG_ER_diArg_1 in sequence Q05586 at position 893

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002064	Q05586 GRIN1 NMDZ1_HUMAN	893	895	STLASSFKRRRSSKDTSTGG	TP	---	Homo sapiens (Human)	938

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0101	sequence based prediction	in silico	Scott,2001	support	certain	InteractionDetection
experimental	MI:0573	mutation disrupting interaction	in vivo/in vitro	Scott,2001	support	certain
experimental	MI:0663	confocal microscopy	in vivo/in vitro	Scott,2001	support	certain	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Scott,2001	support	certain
experimental	MI:0074	mutation analysis	in vivo/in vitro	Scott,2001	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000195:

Phosphorylation of S896 adjacent to the ER retention motif of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) by PKC subfamily (and possibly S897 by PKA) inactivates the motif and promotes delivery of the receptor to the plasma membrane. Optimal trafficking upon dual phosphorylation of S896 and S897 allows regulation of receptor trafficking by coordinated PKA and PKC signaling.

Pathways

KEGG: The sequence Q05586 is implicated in the following 18 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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