ELM - instance TRG_ER_diArg_1 in sequence P49685 at position 352

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002071	P49685 GPR15 GPR15_HUMAN	352	354	LSTFIHAEDFARRRKRSVSL	TP	---	Homo sapiens (Human)	360

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Okamoto,2011	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Okamoto,2011	support	certain	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Okamoto,2011	support	certain
experimental	MI:0005	alanine scanning	in vivo/in vitro/in silico	Okamoto,2011	support	certain	FeatureDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Okamoto,2011	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Okamoto,2011	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000319:

Phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB) promotes cell surface expression of G-protein coupled receptor 15 (GPR15) by releasing the receptor from the ER retrieval/retention pathway that is mediated by the interaction of its ER retention motif with Coatomer subunit beta (COPB1).

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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