ELM - instance TRG_ER_diArg_1 in sequence P04233 at position 3

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002072	P04233 CD74 HG2A_HUMAN	3	5	MHRRRSRSCREDQKPVMDDQ	TP	---	Homo sapiens (Human)	296

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0051	fluorescence technology		Schutze,1994	support	likely	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Schutze,1994	support	likely	InteractionDetection
experimental	MI:0403	colocalization	in vitro	Schutze,1994	support	likely
experimental	MI:0074	mutation analysis	in vivo/in vitro	Schutze,1994	support	likely	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000320:

The basic ER retention motif of HLA class II histocompatibility antigen gamma chain (CD74) is blocked from binding to Coatomer subunit beta (COPB1) by phosphorylation-induced binding of 14-3-3 protein beta/alpha (YWHAB), regulating its release from the ER and trafficking to the plasma membrane.

Pathways

KEGG: The sequence P04233 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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