| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002096 | Q13541 EIF4EBP1 4EBP1_HUMAN |
54 | 60 | GGTRIIYDRKFLMECRNSPV | TP | --- | Homo sapiens (Human) | 118 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0403 | colocalization | in vitro | Marcotrigiano,1999 | support | certain | |
| experimental | MI:0018 | two hybrid | in vivo | Ptushkina,1999 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P06730) IF4E_HUMAN | PF01652
(IF4E)
Eukaryotic initiation factor 4E |
38 | 200 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000696:
Phosphorylation of S65 flanking the eIF4E-binding motif of Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) by Serine/threonine-protein kinase mTOR (MTOR) inhibits binding to Eukaryotic translation initiation factor 4E (EIF4E) in response to growth factors and nutrients. This results in release of Eukaryotic translation initiation factor 4E (EIF4E), which associates with other initiation factors to form the eIF-4F complex that mediates initiation of translation. However, disruption of the interaction between Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) and Eukaryotic translation initiation factor 4E (EIF4E) has been shown to be dependent on hyperphosphorylation of Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) by FRAP/mTOR, PI3K and ERK pathways. According to the current model, Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) is phosphorylated on multiple residues in a well-defined order. Basal phosphorylation of T37 and T46 serves as a priming event for subsequent serum-induced phosphorylation of T70, which primes for subsequent phosphorylation of S65.
Pathways
- AMPK signaling pathway
- Acute myeloid leukemia
- Cellular senescence
- Chemical carcinogenesis receptor activation
- Choline metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- ErbB signaling pathway
- HIF 1 signaling pathway
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Insulin signaling pathway
- Longevity regulating pathway
- PI3K Akt signaling pathway
- mTOR signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement