ELM - instance LIG_WW_1 in sequence P51170 at position 624

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002169	P51170 SCNN1G SCNNG_HUMAN	624	627	GTQVPGTPPPKYNTLRLERA	TP	---	Homo sapiens (Human)	649

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0007	anti tag coimmunoprecipitation	in vivo	Zhou,2007	support	certain	InteractionDetection
experimental	MI:0256	rna interference	in vivo	Zhou,2007	support	certain	InteractionDetection
experimental	MI:0997	ubiquitinase assay	in vitro	Zhou,2007	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Zhou,2007	support	certain	FeatureDetection
experimental	MI:0113	western blot	in vitro	Zhou,2007	support	certain	ParticipantIdentification FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000323:

Phosphorylation of Isoform Nedd4-2a of E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) by Serine/threonine-protein kinase Sgk1 (SGK1) induces binding to 14-3-3 protein eta (YWHAH). This inhibits (whether allosterically or sterically is not known) interactions of NEDD4L via its WW domains with the PY motif in Amiloride-sensitive sodium channel subunit gamma (SCNN1G) (ENaC). As a result, ENaC does not get degraded and ENaC-mediated Na+ currents increase.

Pathways

KEGG: The sequence P51170 is implicated in the following 2 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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