ELM - instance LIG_SH3_3 in sequence O00499-6 at position 308

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002443	O00499-6 BIN1 BIN1_HUMAN	308	314	SQLRKGPPVPPPPKHTPSKE	TP	---	Homo sapiens (Human)	482

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0017	classical fluorescence spectroscopy	in vitro	Pineda-Lucena,2005	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Pineda-Lucena,2005	support	certain	InteractionDetection
experimental	MI:0077	nuclear magnetic resonance	in vitro	Pineda-Lucena,2005	support	certain	InteractionDetection FeatureDetection
experimental	MI:0405	competition binding	in vitro	Pineda-Lucena,2005	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Pineda-Lucena,2005	support	certain	FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000324:

An intramolecular interaction of an SH3 binding motif, encoded by exon 12A, in Isoform II2 of Myc box-dependent-interacting protein 1 (BIN1) with the SH3 domain of Bin1 prevents interaction of the Bin1 SH3 domain with the SH3 binding motif of Myc proto-oncogene protein (MYC).

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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