ELM - instance DEG_SCF_COI1_1 in sequence Q9LMA8 at position 203

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002515	Q9LMA8 TIFY10A TI10A_ARATH	203	220	PIARRASLHRFLEKRKDRVT	TP	3OGL	Arabidopsis thaliana (Thale cress)	253

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0018	two hybrid	in vivo	Thines,2007	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Melotto,2008	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Melotto,2008	support	certain	FeatureDetection
experimental	MI:0096	pull down	in vivo/in vitro	Melotto,2008	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Sheard,2010	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Sheard,2010	support	certain	FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Sheard,2010	support	certain	InteractionDetection FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000719:

Binding of Protein TIFY 10A (TIFY10A) to Coronatine-insensitive protein 1 (COI1), an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone jasmonate to COI1, as this pre-assembled complex provides a composite binding site for the degron motif in TIFY10A. Subsequent ubiquitylation of TIFY10A by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to jasmonate.

Pathways

KEGG: The sequence Q9LMA8 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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