ELM - instance DEG_SCF_TIR1_1 in sequence Q38825 at position 82

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002523	Q38825 IAA7 IAA7_ARATH	82	94	AKAQVVGWPPVRNYRKNMMT	TP	2P1Q	Arabidopsis thaliana (Thale cress)	243

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Gray,2001	support	certain
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Gray,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Gray,2001	support	certain	FeatureDetection
experimental	MI:0114	x-ray crystallography	in vitro	Tan,2007	support	certain	InteractionDetection FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000712:

Binding of Auxin-responsive protein IAA7 (IAA7) to Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1), an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone 22676" target="_blank">auxin to TIR1, as this pre-assembled complex provides a composite binding site for the degron motif in IAA7. Subsequent ubiquitylation of IAA7 by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to auxin.

Pathways

KEGG: The sequence Q38825 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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