ELM - instance LIG_SH3_2 in sequence O55207 at position 1120

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002584	O55207 Synj2 SYNJ2_RAT	1120	1125	VPNRPRPPHPPQRPPPPTGL	TP	---	Rattus norvegicus (Norway rat)	1496

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0004	affinity chromatography technology	in vivo/in vitro	Nemoto,2001	support	certain	InteractionDetection
experimental	MI:0047	far western blotting	in vitro	Nemoto,2001	support	certain	InteractionDetection
experimental	MI:0018	two hybrid	in vivo	Nemoto,2001	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Nemoto,2001	support	certain	FeatureDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Notes
(O08838) AMPH_RAT	PF14604 (SH3_9) Variant SH3 domain	617	680	[mitab][xml]
(O08839) BIN1_RAT	PF14604 (SH3_9) Variant SH3 domain	522	585	[mitab][xml]
(O35964) SH3G1_RAT	PF00018 (SH3_1) SH3 domain	312	357	[mitab][xml]
(O35179) SH3G2_RAT	PF14604 (SH3_9) Variant SH3 domain	297	345	[mitab][xml]
(O35180) SH3G3_RAT	PF14604 (SH3_9) Variant SH3 domain	293	340	[mitab][xml]

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000591:

Alternative splicing removes the SH3-binding motif of Synaptojanin-2 (Synj2), abrogating binding to Endophilin-A2 (Sh3gl1). Endophilin-A1 (Sh3gl2) and Endophilin-A3 (Sh3gl3) were also shown to bind in this study.

Pathways

KEGG: The sequence O55207 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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