ELM - instance LIG_SUMO_SIM_anti_2 in sequence P29590 at position 554

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI002807	P29590 PML PML_HUMAN	554	565	GEAEERVVVISSSEDSDAEN	TP	---	Homo sapiens (Human)	882

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Shen,2006	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Shen,2006	support	certain	InteractionDetection
experimental	MI:0113	western blot	in vitro	Shen,2006	support	certain	ParticipantIdentification FeatureDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000707:

Alternative splicing removes the Sumoylation interacting motif (SIM) of Protein PML (PML), abrogating binding to Small ubiquitin-related modifier 1 (SUMO1) in Isoform TRIM19epsilon of Protein PML (PML). Isoforms lacking the SIM were resistant to As2O3-induced PML degradation.

Pathways

KEGG: The sequence P29590 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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