| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI003692 | P35568 IRS1 IRS1_HUMAN |
896 | 899 | PEPKSPGEYVNIEFGSDQSG | TP | --- | Homo sapiens (Human) | 1242 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0405 | competition binding | in vitro | Skolnik,1993 | support | certain | InteractionDetection |
| experimental | MI:0968 | biosensor | Skolnik,1993 | support | certain | InteractionDetection | |
| experimental | MI:0113 | western blot | in vitro | Skolnik,1993 | support | certain | ParticipantIdentification FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Skolnik,1993 | support | certain | InteractionDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (P62993) GRB2_HUMAN | PF00017
(SH2)
SH2 domain |
60 | 135 | 0.035/0.035 | [mitab][xml] |
Pathways
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Aldosterone regulated sodium reabsorption
- Alzheimer disease
- Autophagy animal
- Diabetic cardiomyopathy
- FoxO signaling pathway
- Growth hormone synthesis, secretion and action
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway multiple species
- MicroRNAs in cancer
- Neurotrophin signaling pathway
- Non alcoholic fatty liver disease
- PI3K Akt signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP PKG signaling pathway
- mTOR signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement