The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

ELM candidate motifs

ELM annotation process is a tedious and time-consuming process involving critical reading of primary and secondary literature, finding motif instances, generating multiple sequence alignments and more. In order not to loose track of possible annotations, we keep the following list of candidate motifs.
We invite researchers to send us their feedback and expert opinion on these classes and to contribute novel motif classes that will be added to the candidate page and ultimately be turned into full ELM classes. Minimum requirements are at least one literature reference as well as a short description. In addition, a draft regular expression or a 3D structure showing the relevant interaction would also be helpful.

Currently 2 candidates need annotation: (Add a new candidate)

Detailed Status:
annotatable: 2
Identifier Model References Description Notes Status
LIG_CENPC_LxxLFL_1 F..[LM][FLY]LE[^P][VAIL] 35420891,29280735 Helical LxxLFL motif in CENP-C binding to the CENP-HIKM interface as part of the inner kinetochore. A second motif in CENP-C DEFxIDE binds to CENP-LN. annotatable
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LIG_MOB1_1 [YF].([ST])[AV][AV] 23579499
4JIZ
Interaction in the mitotic exit network (MEN) or HIPPO pathway. Cell cycle motif modified by Cdc15 kinase and then bound by Mob1 Should be possible to derive motif by alignment due to deep conservation in eukaryotes. But should check if yeast and metazoan motifs can be represented together. annotatable
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Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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