The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002523 Q38825 IAA7
Arabidopsis thaliana (Thale cress) 243

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Gray,2001 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Gray,2001 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Gray,2001 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Tan,2007 support certain InteractionDetection FeatureDetection

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000712:
    ELM Switch SWTI000712

    Binding of Auxin-responsive protein IAA7 (IAA7) to Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1), an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone 22676" target="_blank">auxin to TIR1, as this pre-assembled complex provides a composite binding site for the degron motif in IAA7. Subsequent ubiquitylation of IAA7 by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to auxin.

o  Pathways

KEGG: The sequence Q38825 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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