The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002064 Q05586 GRIN1
NMDZ1_HUMAN
893 895 STLASSFKRRRSSKDTSTGG TP --- Homo sapiens (Human) 938

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0101 sequence based prediction in silico Scott,2001 support certain InteractionDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Scott,2001 support certain
experimental MI:0663 confocal microscopy in vivo/in vitro Scott,2001 support certain InteractionDetection
experimental MI:0403 colocalization in vitro Scott,2001 support certain
experimental MI:0074 mutation analysis in vivo/in vitro Scott,2001 support certain FeatureDetection

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000195:
    ELM Switch SWTI000195

    Phosphorylation of S896 adjacent to the ER retention motif of Glutamate [NMDA] receptor subunit zeta-1 (GRIN1) by PKC subfamily (and possibly S897 by PKA) inactivates the motif and promotes delivery of the receptor to the plasma membrane. Optimal trafficking upon dual phosphorylation of S896 and S897 allows regulation of receptor trafficking by coordinated PKA and PKC signaling.

o  Pathways

KEGG: The sequence Q05586 is implicated in the following 15 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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